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Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2\; MIM 130610). Additionally we are shipping DPH1 Antibodies (63) and DPH1 Proteins (16) and many more products for this protein.
Results identified a second homozygous missense variant in DPH1, seen in four members of a founder population, and associated with autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies.
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia.
OVCA1 could inhibit the proliferation of ovarian cancer cells by p16/cyclin D1 (show CCND1 ELISA Kits) pathway, but not by NF-kappaB (show NFKB1 ELISA Kits)
These findings suggest that OVCA1 deficiency in the neural crest contributes to the craniofacial abnormalities in patients with MDS (show MECOM ELISA Kits).
Ovca1 is a tumor suppressor that can modify p53 (show TP53 ELISA Kits)-induced tumorigenesis and suggest that it acts as a positive regulator for cell cycle progression.
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2\; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004
DPH1 homolog (S. cerevisiae)
, diphthamide biosynthesis protein 1-like
, diptheria toxin resistance protein required for diphthamide biosynthesis-like 1
, diphthamide biosynthesis protein 1
, DPH1 homolog
, Diphthamide biosynthesis protein 1
, DPH-like 1
, DPH2-like 1
, candidate tumor suppressor in ovarian cancer 1
, diphthamide biosynthesis protein 2 homolog-like 1
, diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1
, ovarian cancer-associated gene 1 protein
, ovarian tumor suppressor candidate 1
, ovarian cancer-associated gene 1 protein homolog