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DPH5 encodes a component of the diphthamide synthesis pathway. Additionally we are shipping DPH5 Proteins (9) and many more products for this protein.
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The yeast and Chinese hamster homologs of human DPH5 catalyze the trimethylation step in the biosynthesis of diphthamide
Misfolded AR protein in the cytosol thus initiates a cascade of events beginning with JNK (show MAPK8 Antibodies) and culminating in Bax (show BAX Antibodies)-dependent, intrinsic pathway activation, mediated in part by DP5/Hrk (show HRK Antibodies).
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
, diphthamide biosynthesis methyltransferase
, diphthine synthase
, protein x 0011