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DPH5 encodes a component of the diphthamide synthesis pathway. Additionally we are shipping DPH5 Proteins (9) and DPH5 Antibodies (4) and many more products for this protein.
The yeast and Chinese hamster homologs of human DPH5 catalyze the trimethylation step in the biosynthesis of diphthamide
Misfolded AR protein in the cytosol thus initiates a cascade of events beginning with JNK (show MAPK8 ELISA Kits) and culminating in Bax (show BAX ELISA Kits)-dependent, intrinsic pathway activation, mediated in part by DP5/Hrk (show HRK ELISA Kits).
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
, diphthamide biosynthesis methyltransferase
, diphthine synthase
, protein x 0011