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DACH2 is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. Additionally we are shipping DACH2 Antibodies (58) and DACH2 Kits (2) and many more products for this protein.
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Dach2 and Hdac9 (show HDAC9 Proteins) mediate the effects of muscle activity on muscle reinnervation; Myog (show MYOG Proteins) and Gdf5 (show GDF5 Proteins) appear to stimulate muscle reinnervation through parallel pathways
Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach (show DACH1 Proteins) double mutants are present, suggesting differences between Dach (show DACH1 Proteins) and dachshund gene function during embryonic eye and limb formation.
a HDAC (show HDAC3 Proteins)-Dach2-myogenin (show MYOG Proteins) signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle
HDAC4 (show HDAC5 Proteins) is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin (show MYOG Proteins), and nAChR (show CHRNA4 Proteins)
With Dach1 (show DACH1 Proteins), may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct.
Exome sequencing in two brothers with distinct phenotype including congenital language disorder, growth retardation, intellectual disability and urinary and fecal incontinence, identifies missense mutations in ABCD1 and DACH2.
DACH2 is an independent prognostic marker that can be used at initial diagnosis of urothelial carcinoma of the bladder to identify patients who have a high potential to develop metastasis.
Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes. Only one of the six breakpoints disrupts a gene, DACH2.
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene.
dachshund homolog 2
, dachshund homolog 2 (Drosophila)
, dachshund homolog 2-like
, dachshund 2