Damage Specific DNA Binding Protein 1 Proteins (DDB1)

The protein encoded by DDB1 is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. Additionally we are shipping DDB1 Antibodies (90) and DDB1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DDB1 13194 Q3U1J4
DDB1 1642 Q16531
Rat DDB1 DDB1 64470  
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Top DDB1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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DDB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Damage Specific DNA Binding Protein 1 (DDB1) Interaction Partners

Mouse (Murine) Damage Specific DNA Binding Protein 1 (DDB1) interaction partners

  1. SIRT7 (show SIRT7 Proteins) inhibits TR4 (show NR2C2 Proteins) degradation by deacetylation of DDB1.

  2. These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  3. uncovered a novel biological role for CUL4A (show CUL4A Proteins)-DDB1-CDT2 E3 ligase that regulates molecular circadian behaviors via promoting ubiquitination-dependent degradation of CRY1 (show CRY1 Proteins)

  4. UCH-L1 disrupts a complex between the DDB1-CUL4 ubiquitin ligase complex.

  5. In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase (show RNF123 Proteins) complexes catalyzing the obstruction of the STAT2 (show STAT2 Proteins)-dependent antiviral state of cells to permit viral replication.

  6. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.

  7. These results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells.

  8. DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability.

Human Damage Specific DNA Binding Protein 1 (DDB1) interaction partners

  1. SIRT7 (show SIRT7 Proteins) inhibits TR4 (show NR2C2 Proteins) degradation by deacetylation of DDB1.

  2. the c-Abl (show ABL1 Proteins) non-receptor kinase phosphorylates DDB1 at residue Tyr (show TYR Proteins)-316 to recruit a small regulatory protein, DDA1 (show DDA1 Proteins), leading to increased substrate ubiquitination

  3. knockdown of DCAF7 (show DCAF7 Proteins) reduced the degradation of DNA ligase I (show LIG1 Proteins) in response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I (show LIG1 Proteins) by Cul4-DDB1 and DCAF7 (show DCAF7 Proteins). In contrast, a different E3 ubiquitin ligase (show MUL1 Proteins) regulates FEN-1 (show FEN1 Proteins) turnover.

  4. This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (show UNG Proteins) (cyclin U (show CCNO Proteins)) complex.

  5. Our data are consistent with the idea that the CUL4A (show CUL4A Proteins)/B-DDB1-CRBN (show CRBN Proteins) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Proteins) channels.

  6. These results revealed a novel role of DDB in H3K56Ac deacetylation during early step of NER (show NR1H2 Proteins) and the existence of active functional cross-talk between DDB-mediated damage recognition and H3K56Ac deacetylation.

  7. The identification of Vpr mutants which associate with DCAF1 but only poorly with DDB1 suggests that DCAF1 is necessary but is not sufficient for the Vpr association with DDB1-containing E3 ligase complex.

  8. Data support a model wherein DDB1 and DDB2 (show DDB2 Proteins) cooperate to repress Bcl-2 (show BCL2 Proteins) transcription. DDB2 (show DDB2 Proteins) recognizes and binds to the Bcl-2 (show BCL2 Proteins) P1 promoter, and HDAC1 (show HDAC1 Proteins) is recruited through the DDB1 subunit associated with DDB2 (show DDB2 Proteins) to deacetylate histone H3K9.

  9. The study presents the crystal structure of human CRBN (show CRBN Proteins) bound to DDB1 and the drug lenalidomide.

  10. CUL4A (show CUL4A Proteins)-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor (show PEX7 Proteins) Pex7p.

DDB1 Protein Profile

Protein Summary

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Gene names and symbols associated with DDB1

  • damage specific DNA binding protein 1 (Ddb1)
  • damage-specific DNA binding protein 1, 127kDa (DDB1)
  • damage-specific DNA binding protein 1, 127kDa (Ddb1)
  • 127kDa protein
  • AA408517 protein
  • DDBA protein
  • p127-Ddb1 protein
  • UV-DDB1 protein
  • XAP1 protein
  • XPCE protein
  • XPE protein
  • XPE-BF protein

Protein level used designations for DDB1

DDB p127 subunit , DNA damage-binding protein 1 , DNA repair protein , UV-damaged DNA-binding factor , damage-specific DNA-binding protein 1 , damage-specific DNA-binding protein, DNA repair , damaged-DNA recognition protein 1 , DNA damage-binding protein a , HBV X-associated protein 1 , UV-DDB 1 , UV-damaged DNA-binding protein 1 , XAP-1 , XPE-binding factor , xeroderma pigmentosum group E-complementing protein , damage specific DNA binding protein 1

GENE ID SPECIES
13194 Mus musculus
1642 Homo sapiens
64470 Rattus norvegicus
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