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Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) Proteins (DACT1)

The protein encoded by DACT1 belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. Additionally we are shipping DACT1 Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DACT1 59036 Q8R4A3
DACT1 51339 Q9NYF0
Rat DACT1 DACT1 500666  
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Top DACT1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

DACT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) Interaction Partners

Mouse (Murine) Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) interaction partners

  1. Dpr1 promotes the ubiquitination of Dvl2 (show DVL2 Proteins) by pVHL (show VHL Proteins) and mediates the protein aggregate-elicited autophagy initiation

  2. Expression analysis of Dact1-LacZ (show GLB1 Proteins) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.

  3. These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (show DVL1 Proteins) and possibly Disrupted in Schizophrenia-1 (show DISC1 Proteins), in the formation of synapses on cortical interneuron dendrites.

  4. Depletion of Dapper-1 and dishevelled-2 (show DVL2 Proteins) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (show DVL2 Proteins) and that activity of both Dapper-1 and dishevelled-2 (show DVL2 Proteins) is essential for activating canonical Wnt (show WNT2 Proteins) signaling.

  5. conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (show DVL1 Proteins).

  6. Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.

  7. Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (show DVL2 Proteins) activity and leads to posterior malformation in mice.

  8. This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (show AKT1 Proteins)

  9. Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis

  10. Dact1 is detected in the presomitic mesoderm and somites during segmentation, in the limb bud mesenchyme and other mesoderm-derived tissues, and in the central nervous system

Zebrafish Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) interaction partners

  1. frd1 is expressed in the developing brain and mesoderm.

  2. two Dvl (show DVL2 Proteins)-associated paralogs, Dpr1 and Dpr2 (show DACT2 Proteins), participate in distinct Wnt (show WNT2 Proteins)-dependent developmental processes

  3. target of beta-catenin (show CTNNB1 Proteins) and/or an unknown downstream effector in development

Human Dapper, Antagonist of beta-Catenin, Homolog 1 (Xenopus Laevis) (DACT1) interaction partners

  1. Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (show WNT2 Proteins)/beta catenin (show CTNNB1 Proteins) signaling.

  2. our results suggested that DACT1 was upregulated during human placenta development.

  3. There was no statistical difference between groups concerning DACT1 and DACT2 (show DACT2 Proteins) either in promoter hypermethylation or transcript levels. Age was associated with DACT2 (show DACT2 Proteins) promoter hypermethylation, especially over 56 years old.

  4. Dpr1 promotes the ubiquitination of Dvl2 (show DVL2 Proteins) by pVHL (show VHL Proteins) and mediates the protein aggregate-elicited autophagy initiation

  5. Overexpression of Dapper-1 allows the translocation of MIZ-1 (show ZBTB17 Proteins) from the nucleus to the cytoplasm.

  6. Dpr1 directly interacts with Beclin1 (show BECN1 Proteins) and Atg14L and enhances the Beclin1 (show BECN1 Proteins)-Vps34 (show PIK3C3 Proteins) interaction and Vps34 (show PIK3C3 Proteins) activity.

  7. Data indicate that Sestd1 (show SESTD1 Proteins) cooperates with Dact1 in Vangl2 (show VANGL2 Proteins) regulation and in the planar cell polarity (PCP (show PRCP Proteins)) pathway during mammalian embryonic development.

  8. five missense heterozygote mutations of the DACT1 gene are specifically identified in 167 stillborn or miscarried Han Chinese fetuses with neural tube defects.

  9. These findings provided insight into the role of DACT1 as a novel functional tumor suppressor in gastric cancer through inhibiting NF-kappaB (show NFKB1 Proteins) signaling pathway.

  10. DACT1 stabilizes beta-catenin (show CTNNB1 Proteins) via DACT1-induced effects on GSK-3beta and directly interacts with beta-catenin (show CTNNB1 Proteins) proteins.

DACT1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with DACT1

  • dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (DACT1)
  • dapper, antagonist of beta-catenin (dact1)
  • dishevelled-binding antagonist of beta-catenin 1 (DACT1)
  • dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (dact1)
  • dapper homolog 1, antagonist of beta-catenin (xenopus) (Dact1)
  • dapper homolog 1, antagonist of beta-catenin (xenopus) (dact1)
  • dishevelled-binding antagonist of beta-catenin 1 (dact1-b)
  • dishevelled-binding antagonist of beta-catenin 1 (Dact1)
  • 4921528D17Rik protein
  • AI115603 protein
  • dact1 protein
  • DAPPER protein
  • DAPPER1 protein
  • dpr protein
  • DPR1 protein
  • frd1 protein
  • FRODO protein
  • frodo1 protein
  • HDPR1 protein
  • MDpr1 protein
  • MGC89695 protein
  • MTNG3 protein
  • RGD1564008 protein
  • THYEX3 protein
  • XDpr protein
  • XDpr1a protein

Protein level used designations for DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) , dapper 1 , dapper, antagonist of beta-catenin , dapper, antagonist of beta-catenin, homolog 1 , dapper homolog 1-like , dapper antagonist of catenin 1 , dapper homolog 1 , frodo homolog , thymus expressed gene 3 , thymus-expressed novel gene 3 protein , dishevelled-interacting protein , frodo 1 , hepatocellular carcinoma novel gene 3 protein , heptacellular carcinoma novel gene 3 , dapper 1-B , dapper1a , xDpr , dapper homolog 1, antagonist of beta-catenin

GENE ID SPECIES
452938 Pan troglodytes
493325 Xenopus (Silurana) tropicalis
538778 Bos taurus
701218 Macaca mulatta
100021268 Monodelphis domestica
100339172 Oryctolagus cuniculus
100400795 Callithrix jacchus
100437942 Pongo abelii
100546955 Meleagris gallopavo
100555885 Anolis carolinensis
100606126 Nomascus leucogenys
59036 Mus musculus
405799 Danio rerio
723789 Gallus gallus
100687551 Canis lupus familiaris
51339 Homo sapiens
399186 Xenopus laevis
500666 Rattus norvegicus
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