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Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors (By similarity).. Additionally we are shipping Dapper, Antagonist of beta-Catenin, Homolog 2 (Xenopus Laevis) Proteins (3) and many more products for this protein.
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Human Polyclonal DACT2 Primary Antibody for IHC, ELISA - ABIN1031341
Zhang, Yang, Liu, Herman, Brock, Licchesi, Yue, Pei, Guo: Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma. in Epigenetics : official journal of the DNA Methylation Society 2013
we have identified a novel role for Dact2 as an inhibitor of the canonical Wnt (show WNT2 Antibodies) pathway in embryonic tooth development through its regulation of cell proliferation and differentiation.
conserved role for Dact2 protein in kinase-regulated biochemistry involving Vangl and Dvl (show DVL1 Antibodies).
Dact2 plays a role in regulating morphogenesis by renal collecting duct cells, probably by protecting cells from overly strong TGF-beta (show TGFB1 Antibodies) pathway activation.
Dact2 may play important signal-modulating roles in the adjacent epithelial cells including the enamel knot (show KCNK7 Antibodies) signaling centers and pre-ameloblasts.
Dact2 expression is most prominent during organogenesis of the thymus, kidneys, and salivary glands, with much lower levels in the somites and in the developing CNS.
Dpr2 plays an inhibitory role in the re-epithelialization of adult skin wounds by attenuating TGFbeta (show TGFB1 Antibodies) signaling.
The simultaneous methylation of DACT1 (show DACT1 Antibodies) and DACT2 may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
DACT2 is frequently methylated in human esophageal cancer and its expression is regulated by promoter region methylation. DACT2 suppresses esophageal cancer growth by inhibiting Wnt (show WNT2 Antibodies) signaling.
This study demonstrated that Genes overexpressed in Pilomyxoid Astrocytoma vs. Pilocytic Astrocytoma, ranked according to fold-change, included developmental genes H19 (show NCKAP1 Antibodies), DACT2,COL2A1 (show COL2A1 Antibodies); COL1A1 (show COL1A1 Antibodies) and IMP3 (show IGF2BP3 Antibodies).
DACT2 suppresses papillary thyroid cancer proliferation and metastasis by inhibiting Wnt (show WNT2 Antibodies) signaling.
There was no statistical difference between groups concerning DACT1 (show DACT1 Antibodies) and DACT2 either in promoter hypermethylation or transcript levels. Age was associated with DACT2 promoter hypermethylation, especially over 56 years old.
DACT2 acts as a functional tumor suppressor in colon cancer through inhibiting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling. Its methylation at early stages of colon carcinogenesis is an independent prognostic factor.
DACT2 suppresses hepatocellular carcinoma by inhibiting Wnt (show WNT2 Antibodies) signaling in human hepatocellular carcinoma cells.
Loss of DACT2 expression is associated with esophageal squamous cell carcinoma.
Reduced expression of DACT2 due to methylation-mediated gene silencing promotes hepatocellular carcinoma progression
Epigenetic regulation of DACT2 is a key component of the Wnt (show WNT2 Antibodies) signalling pathway in human lung cancer.
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors (By similarity).
dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
, dapper homolog 2-like
, dapper antagonist of catenin 2
, dapper homolog 2
, dapper, antagonist of beta-catenin, homolog 2
, dapper homolog 2, antagonist of beta-catenin