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Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors (By similarity).. Additionally we are shipping Dapper, Antagonist of beta-Catenin, Homolog 2 (Xenopus Laevis) Antibodies (14) and many more products for this protein.
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we have identified a novel role for Dact2 as an inhibitor of the canonical Wnt (show WNT2 Proteins) pathway in embryonic tooth development through its regulation of cell proliferation and differentiation.
conserved role for Dact2 protein in kinase-regulated biochemistry involving Vangl and Dvl (show DVL1 Proteins).
Dact2 plays a role in regulating morphogenesis by renal collecting duct cells, probably by protecting cells from overly strong TGF-beta (show TGFB1 Proteins) pathway activation.
Dact2 may play important signal-modulating roles in the adjacent epithelial cells including the enamel knot signaling centers and pre-ameloblasts.
Dact2 expression is most prominent during organogenesis of the thymus, kidneys, and salivary glands, with much lower levels in the somites and in the developing CNS.
Dpr2 plays an inhibitory role in the re-epithelialization of adult skin wounds by attenuating TGFbeta (show TGFB1 Proteins) signaling.
The simultaneous methylation of DACT1 (show DACT1 Proteins) and DACT2 may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
DACT2 is frequently methylated in human esophageal cancer and its expression is regulated by promoter region methylation. DACT2 suppresses esophageal cancer growth by inhibiting Wnt (show WNT2 Proteins) signaling.
This study demonstrated that Genes overexpressed in Pilomyxoid Astrocytoma vs. Pilocytic Astrocytoma, ranked according to fold-change, included developmental genes H19 (show NCKAP1 Proteins), DACT2,COL2A1 (show COL2A1 Proteins); COL1A1 (show COL1A1 Proteins) and IMP3 (show IGF2BP3 Proteins).
DACT2 suppresses papillary thyroid cancer proliferation and metastasis by inhibiting Wnt (show WNT2 Proteins) signaling.
There was no statistical difference between groups concerning DACT1 (show DACT1 Proteins) and DACT2 either in promoter hypermethylation or transcript levels. Age was associated with DACT2 promoter hypermethylation, especially over 56 years old.
DACT2 acts as a functional tumor suppressor in colon cancer through inhibiting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling. Its methylation at early stages of colon carcinogenesis is an independent prognostic factor.
DACT2 suppresses hepatocellular carcinoma by inhibiting Wnt (show WNT2 Proteins) signaling in human hepatocellular carcinoma cells.
Loss of DACT2 expression is associated with esophageal squamous cell carcinoma.
Reduced expression of DACT2 due to methylation-mediated gene silencing promotes hepatocellular carcinoma progression
Epigenetic regulation of DACT2 is a key component of the Wnt (show WNT2 Proteins) signalling pathway in human lung cancer.
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors (By similarity).
dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
, dapper homolog 2-like
, dapper antagonist of catenin 2
, dapper homolog 2
, dapper, antagonist of beta-catenin, homolog 2
, dapper homolog 2, antagonist of beta-catenin