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Dead End Homolog 1 (Zebrafish) Proteins (DND1)

DND1 encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Additionally we are shipping Dead End Homolog 1 (Zebrafish) Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DND1 213236 Q6VY05
DND1 373863 Q8IYX4
Rat DND1 DND1 679841  
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Top Dead End Homolog 1 (Zebrafish) Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

DND1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Dead End Homolog 1 (Zebrafish) (DND1) Interaction Partners

Mouse (Murine) Dead End Homolog 1 (Zebrafish) (DND1) interaction partners

  1. DND1 interacts with NANOS2 (show NANOS2 Proteins) to load unique RNAs into the CCR4 (show CCR4 Proteins)-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2 (show NANOS2 Proteins), which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 (show NANOS2 Proteins) that leads to the degradation of specific RNAs in male germ cell development

  2. Dnd1 heterozygotes, lower oxygen availability was associated with metabolic differences

  3. APOBEC3G (show APOBEC3G Proteins) inhibits DND1 function to regulate microRNA activity.

  4. results show that Dnd1 is essential for normal allelic inheritance and that Dnd1Ter has a novel combination of functions that significantly increase risk for both testicular and intestinal cancer

  5. DND1 is the first protein known to have an RNA recognition motif directly implicated as a heritable cause of spontaneous tumorigenesis

  6. DND1-alpha isoform to be necessary for germ cell viability and its loss in Ter (show TECR Proteins) mice results in germ cell depletion, germ cell tumor development and partial embryonic lethality in the 129 strain.

  7. The role of dead-end in germ-cell tumor development.

  8. The interaction of DND1 and APOBEC3 could be one mechanism for maintaining viability of germ cells and for preventing germ cell tumor development

  9. when Dnd1(Ter/Ter) XX germ cells developed in a testicular environment they gave rise to the same neoplastic clusters as mutant XY germ cells in a testis.

Human Dead End Homolog 1 (Zebrafish) (DND1) interaction partners

  1. RBM38 (show RBM38 Proteins) and DND1 are repressed in primary acute myeloid leukemia (show BCL11A Proteins), neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1 (show CDKN1A Proteins)) expression during acute promyelocytic leukemia (show PML Proteins) differentiation

  2. APOBEC3G (show APOBEC3G Proteins) inhibits DND1 function to regulate microRNA activity.

  3. The increased sensitivity of transformed keratinocytes to miR (show MLXIP Proteins)-21's effects occurs in part through downregulation of the RNA-binding protein (show PTBP1 Proteins) DND1 during the transformation process.

  4. Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells.

  5. We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility

  6. Cloning of zebrafish dnd1 and identification of human DND1 by database analysis.

  7. Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression.

  8. MiR (show MLXIP Proteins)-24 up-regulation reduced the expression of RNA-binding protein (show PTBP1 Proteins) dead end 1 (show VPS11 Proteins) (DND1). Knockdown of miR (show MLXIP Proteins)-24 led to enhanced expression of DND1.

  9. The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility

Dead End Homolog 1 (Zebrafish) (DND1) Protein Profile

Protein Summary

This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17.

Gene names and symbols associated with DND1

  • dead end homolog 1 (dnd1)
  • dead end homolog 1 (LOC100349427)
  • dead end homolog 1 (zebrafish) (DND1)
  • dead end homolog 1 (zebrafish) (Dnd1)
  • DND microRNA-mediated repression inhibitor 1 (DND1)
  • DND microRNA-mediated repression inhibitor 1 (Dnd1)
  • BC034897 protein
  • dead-end protein
  • dnd protein
  • DND1 protein
  • RBMS4 protein
  • Ter protein
  • xde protein
  • Xdead protein

Protein level used designations for DND1

dead end homolog 1 , dead end homolog 1 (zebrafish) , dead end protein homolog 1-like , dead end protein homolog 1 , RNA-binding motif, single-stranded-interacting protein 4 , teratoma

GENE ID SPECIES
733500 Xenopus (Silurana) tropicalis
100349427 Oryctolagus cuniculus
425270 Gallus gallus
462121 Pan troglodytes
100061778 Equus caballus
100441044 Pongo abelii
100604987 Nomascus leucogenys
607141 Canis lupus familiaris
525516 Bos taurus
213236 Mus musculus
373863 Homo sapiens
679841 Rattus norvegicus
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