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DEDD encodes a protein that contains a death effector domain (DED). Additionally we are shipping DEDD Antibodies (51) and many more products for this protein.
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Human DEDD Protein expressed in Escherichia coli (E. coli) - ABIN1098762
Schickling, Stegh, Byrd, Peter: Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. in Cell death and differentiation 2001
Show all 2 references for ABIN1098762
Via direct interaction with the class III PI-3 (show PI3 Proteins)-kinase (PI3KC3)/Beclin1 (show BECN1 Proteins), DEDD activated autophagy and induced the degradation of Snail (show SNAI1 Proteins) and Twist, two master regulators of EMT (show ITK Proteins)
FAS (show FAS Proteins)-associated death domain (FADD (show FADD Proteins))-DED (show AATF Proteins)-induced reactive oxygen species (ROS (show ROS1 Proteins)) generation is triggered by membrane localization of FADD (show FADD Proteins)-DED (show AATF Proteins), which shifts the cells into a state that stimulates and fuels ROS (show ROS1 Proteins) and ultimately results in cell death.
DEDD forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC
DEDD and DEDD2 (show DEDD2 Proteins) may be important mediators for death receptors and that they may target caspases to the nucleus.
In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation.
DEDD plays an important role in maintenance of the Akt (show AKT1 Proteins) protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues.
DEDD acts as a novel inhibitor of the mitotic Cdk1 (show CDK1 Proteins)/cyclin B1 (show CCNB1 Proteins) complex and is an impeder of cell mitosis, and its absence critically influences cell and body size via modulation of rRNA synthesis
The death effector domain-containing DEDD supports S6K1 (show RPS6KB1 Proteins) activity via preventing Cdk1 (show CDK1 Proteins)-dependent inhibitory phosphorylation.
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
, death effector domain-containing protein
, death effector domain-containing testicular molecule
, tumor necrosis factor (ligand) superfamily, member 19