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Death Inducer-Obliterator 1 Proteins (DIDO1)

The protein encoded by DIDO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. Additionally we are shipping Death Inducer-Obliterator 1 Antibodies (51) and Death Inducer-Obliterator 1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DIDO1 11083 Q9BTC0
Mouse DIDO1 DIDO1 23856 Q8C9B9
Rat DIDO1 DIDO1 362286  
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
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DIDO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Death Inducer-Obliterator 1 (DIDO1) Interaction Partners

Human Death Inducer-Obliterator 1 (DIDO1) interaction partners

  1. All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 function in HepG2 cells.

  2. Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.

  3. The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase (show DIO1 Proteins) in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.

  4. [review] Deiodinase type 1 polymorphisms particularly show moderate-to-strong relationships with thyroid hormone (show PTH Proteins) parameters, insulin (show INS Proteins)-like growth factor (IGF)1 (show IGF1 Proteins) protein production, and risk for depression.

  5. a new mechanism of posttranscriptional regulation of DIO1 and show deregulation of DIO1 expression in pituitary adenoma, possibly resulting from disturbed expression of SF2/ASF (show SRSF1 Proteins).

  6. Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells.

  7. Data show that CSE1L (show CSE1L Proteins), DIDO1 and RBM39 (show RBM39 Proteins) mRNA expression levels correlated with chromosome 20q DNA copy number status.

  8. Data indicate that type 1 deiodinase (show DIO1 Proteins) is subject to catalysis-induced loss of activity.

  9. investigation of DIO1 and DIO2 (show DIO2 Proteins) activities in 66 thyroid tissue samples from follicular thyroid adenoma, toxic diffuse goiter, nontoxic multinodular goiter, papillary thyroid carcinoma, and surrounding normal tissues

  10. Short interfering RNA-mediated knockdown of FOXA1 (show FOXA1 Proteins) decreased the expression of DIO1 mRNA, but knockdown of both FOXA1 (show FOXA1 Proteins) and FOXA2 (show FOXA2 Proteins) restored it.

Mouse (Murine) Death Inducer-Obliterator 1 (DIDO1) interaction partners

  1. Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6 (show HDAC6 Proteins)) is a key determinant of cilium size in growth-arrested cells

  2. Dido1 is able to regulate self-renewal of mouse embryonic stem cells.

  3. Dido3 PHD (show PDC Proteins) interacts with histone H3K4me3 and regulates expression of stemness genes in embryonic stem cells.

  4. loss of Dido3 expression compromises differentiation of embryonic stem cells in vitro and of epiblast cells in vivo, resulting in early embryonic death at around day 8.5 of gestation

  5. Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein (show BLOC1S2 Proteins) whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint (show BUB3 Proteins) protein BubR1 (show BUB1B Proteins).

  6. results indicate that histone H3 (show HIST3H3 Proteins) lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex

Death Inducer-Obliterator 1 (DIDO1) Protein Profile

Protein Summary

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

Gene names and symbols associated with DIDO1

  • death inducer-obliterator 1 (DIDO1)
  • death inducer-obliterator 1 (LOC100226813)
  • death inducer-obliterator 1 (LOC100341075)
  • death inducer-obliterator 1 (dido1)
  • death inducer-obliterator 1 (Dido1)
  • deiodinase, iodothyronine, type I (DIO1)
  • 5DI protein
  • 6720461J16Rik protein
  • BYE1 protein
  • C20orf158 protein
  • C530043I07 protein
  • D130048F08Rik protein
  • DATF-1 protein
  • Datf1 protein
  • datf1l protein
  • DIDO1 protein
  • Dido2 protein
  • Dido3 protein
  • DIO-1 protein
  • DIO1 protein
  • dJ885L7.8 protein
  • DKFZp469J1523 protein
  • fi35b04 protein
  • mKIAA0333 protein
  • TXDI1 protein
  • wu:fi35b04 protein
  • zgc:158157 protein

Protein level used designations for DIDO1

death inducer-obliterator 1 , death-inducer obliterator 1-like , death-associated transcription factor 1 , death-inducer obliterator 1 , DATF-1 , death inducer-obliterator-2 , death inducer-obliterator-3 , death associated transcription factor 1 , datf1 , DIOI , thyroxine deiodinase type I (selenoprotein) , type 1 DI , type I iodothyronine deiodinase , type-I 5'-deiodinase

GENE ID SPECIES
458396 Pan troglodytes
698313 Macaca mulatta
100171797 Pongo abelii
100226813 Taeniopygia guttata
100341075 Oryctolagus cuniculus
100481275 Ailuropoda melanoleuca
100135007 Xenopus (Silurana) tropicalis
100584690 Nomascus leucogenys
11083 Homo sapiens
23856 Mus musculus
419234 Gallus gallus
519826 Bos taurus
362286 Rattus norvegicus
485965 Canis lupus familiaris
553277 Danio rerio
494751 Xenopus laevis
1733 Homo sapiens
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