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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Additionally we are shipping DAP3 Antibodies (120) and DAP3 Proteins (5) and many more products for this protein.
DAP3 plays important roles in mitochondrial function and dynamics
DAP3 silencing contributes to breast carcinogenesis.
Knockdown of DAP3 expression promoted cell migration.
Study demonstrates an inverse association between DAP3 mRNA levels and tumour stage and clinical outcome in breast cancer.
identified a novel DAP3-binding protein termed death ligand signal enhancer (DELE (show KIAA0141 ELISA Kits)); results demonstrated the biological significance of DELE (show KIAA0141 ELISA Kits) for apoptosis signal mediated by death receptors
show that interferon-beta (show IFNB1 ELISA Kits) promoter stimulator 1 (IPS-1 (show MAVS ELISA Kits)) binds DAP3 and induces anoikis by caspase (show CASP3 ELISA Kits) activation.
Functional interaction between the pro-apoptotic DAP3 and the glucocorticoid receptor (show NR3C1 ELISA Kits)
DAP3 has a role in the molecular pathway that culminates in fragmented mitochondria
DAP3 gene might be associated with the mechanisms responsible for adult bronchial asthma and contribute to airway inflammation and remodeling
DAP3 has a role in anoikis signaling and in apoptosis induction caused by cell detachment
Both constitutive and induced genetic deletion of the melanocortin 4 receptor (show MC4R ELISA Kits) gene(MC4R (show MC4R ELISA Kits)) normalizes compulsive grooming and striatal electrophysiologic impairments in SAPAP3 (show DLGAP3 ELISA Kits)-null mice
These results identify a role for SAPAP3 (show DLGAP3 ELISA Kits) in the regulation of postsynaptic metabotropic glutamate (show GRIN1 ELISA Kits) receptors and endocannabinoid-mediated synaptic plasticity.
DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77 (show NR4A1 ELISA Kits).
Semi-quantitative analysis of RNA levels in FMRP (show FMR1 ELISA Kits) immunoprecipitates showed that in the mouse brain mRNAs encoding PSD (show PSD ELISA Kits) components, such as Shank1 (show SHANK1 ELISA Kits), SAPAP1 (show DLGAP1 ELISA Kits)-3, PSD-95 (show DLG4 ELISA Kits), and the glutamate (show GRIN1 ELISA Kits) receptor subunits NR1 (show GRIN1 ELISA Kits) and NR2B (show GRIN2B ELISA Kits), are associated with FMRP (show FMR1 ELISA Kits).
DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction.
requirement for DAP3 in mitochondrial respiration was also revealed by oxygen consumption measurements using cultured cells treated with DAP3-specific small interfering RNA
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.
death-associated protein 3
, 28S ribosomal protein S29, mitochondrial
, ionizing radiation resistance conferring protein
, mitochondrial 28S ribosomal protein S29
, PSD-95/SAP90-binding protein 3
, SAP90/PSD 95 associated protein 3
, disks large-associated protein 3
, prion protein ligand 8