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The protein encoded by DBR1 is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. Additionally we are shipping DBR1 Antibodies (24) and DBR1 Proteins (13) and many more products for this protein.
saturation mutagenesis of DBR1 and Gal4 (show LGALS4 ELISA Kits) and show that the experimental phenotypes for over 80% of the mutations correlate well with predicted effects of mutations on protein stability and RNA binding affinity.
Results of protein-protein interaction between human Dbr1 and factors found in the Intron Large complex identify Xab2 (show XAB2 ELISA Kits) and a novel protein CWF19L1 as specific interactors of DBR1.
Inhibition of DBR1 caused a significant reduction in the formation of intermediate and full-length HIV-1 cDNA.
Dbr1 protein cleaves the 2'-5' phosphodiester bond of intron lariats, necessary for subsequent intron degradation that follows pre-mRNA splicing.
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication.
lariat debranching enzyme
, debranching enzyme homolog 1 (S. cerevisiae)
, lariat debranching enzyme-like
, RNA lariat debranching enzyme
, debranching enzyme homolog 1