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Decapping Enzyme, Scavenger Proteins (DCPS)

Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Additionally we are shipping Decapping Enzyme, Scavenger Antibodies (40) and Decapping Enzyme, Scavenger Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCPS 28960 Q96C86
DCPS 69305 Q9DAR7
DCPS 266605 Q8K4F7
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Top Decapping Enzyme, Scavenger Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,905.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,907.67
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,907.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DCPS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Decapping Enzyme, Scavenger Proteins

  1. Human DCPS Protein expressed in Escherichia coli (E. coli) - ABIN667946 : Kwasnicka, Krakowiak, Thacker, Brenner, Vincent: Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN667946

More Proteins for Decapping Enzyme, Scavenger (DCPS) Interaction Partners

Human Decapping Enzyme, Scavenger (DCPS) interaction partners

  1. Data show that decapping scavenger enzyme DcpS (DcpS) is a nucleocytoplasmic shuttling protein that activates microRNA (miRNA) degradation.

  2. In DcpS, conformational change is dominated by an anti-symmetric cooperative motion, causing one active site to close as the other opens; however a symmetric motion is also significant.

  3. In vitro decapping assays showed that altered EDC3 (show EDC3 Proteins) is unable to enhance DCP2 (show DCP2 Proteins) decapping at low concentrations and even inhibits DCP2 (show DCP2 Proteins) decapping at high concentration.

  4. DCPS and more generally RNA catabolism, are critical for neurological development, normal cognition and organismal homeostasis in humans.

  5. data demonstrate that DcpS in conjunction with Xrn1 has the potential to regulate RNA stability in a transcript-selective manner in mammalian cells

  6. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.

  7. m7GDP breakdown by DcpS should prevent misincorporation of methylated nucleotides in nucleic acids and could generate a unique indicator allowing the cell to monitor mRNA decay.

  8. crystal structures of DcpS in ligand-free form and in a complex with m7GDP

  9. Furthermore, we show that a novel human histidine triad protein DCS-1, which is expressed together with NR1 in many tissues, can significantly reduce menadione-induced cytotoxicity in these cells

  10. These studies demonstrate that the significance of DcpS extends beyond its well-characterized role in mRNA decay and involves a broader range of functions in RNA processing including nuclear pre-mRNA splicing.

Mouse (Murine) Decapping Enzyme, Scavenger (DCPS) interaction partners

Decapping Enzyme, Scavenger (DCPS) Protein Profile

Protein Summary

Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.

Gene names and symbols associated with DCPS

  • decapping enzyme, scavenger (DCPS)
  • decapping enzyme, scavenger (dcps)
  • decapping enzyme, scavenger (Dcps)
  • 1700001E16Rik protein
  • AA408441 protein
  • DCPS protein
  • DCS1 protein
  • Hint-5 protein
  • HINT5 protein
  • HSL1 protein

Protein level used designations for DCPS

decapping enzyme, scavenger , DCS-1 , decapping scavenger enzyme , heat shock-like protein 1 , hint-related 7meGMP-directed hydrolase , histidine triad nucleotide-binding protein 5 , histidine triad protein member 5 , homolog of C. elegans 7meGMP-directed hydrolase dcs-1 , m7GpppX diphosphatase , mRNA decapping enzyme , scavenger mRNA-decapping enzyme DcpS , HINT-5

GENE ID SPECIES
419716 Gallus gallus
609536 Canis lupus familiaris
100216298 Xenopus (Silurana) tropicalis
28960 Homo sapiens
69305 Mus musculus
266605 Rattus norvegicus
282640 Bos taurus
396689 Sus scrofa
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