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Dedicator of Cytokinesis 1 Proteins (DOCK1)

DOCK1 product binds to the SH3 domain of CRK protein. Additionally we are shipping Dedicator of Cytokinesis 1 Antibodies (65) and Dedicator of Cytokinesis 1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DOCK1 DOCK1 313438  
DOCK1 1793 Q14185
Mouse DOCK1 DOCK1 330662 Q8BUR4
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Top Dedicator of Cytokinesis 1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details

DOCK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Dedicator of Cytokinesis 1 (DOCK1) Interaction Partners

Zebrafish Dedicator of Cytokinesis 1 (DOCK1) interaction partners

  1. A novel signaling cascade is identified in which ELMO1 (show ELMO1 Proteins)/DOCK180 regulates vasculature formation in zebrafish.

  2. The fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein.

Human Dedicator of Cytokinesis 1 (DOCK1) interaction partners

  1. Thus, Elmo1 (show ELMO1 Proteins) and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.

  2. High DOCK180 expression is associated with serous ovarian cancer.

  3. our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180

  4. findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis

  5. Dock180 could act as a pro-survival molecule in H9C2 cardiomyocytes via activation of its downstream pro-survival signaling molecule, AKT (show AKT1 Proteins).

  6. Solved is the solution structure of DOCK180 SH3 domain, which shares similar target binding features with the SH3 domain of DOCK2.

  7. DOCK1-Rac (show AKT1 Proteins) signaling as an HER2 (show ERBB2 Proteins) effector pathway essential for HER2 (show ERBB2 Proteins)-mediated breast cancer progression to metastasis.

  8. Phosphorylation of Dock180(Y1811) enhanced its association with CrkII (show CRK Proteins) & p130(Cas (show BCAR1 Proteins)). Dock180 associated with PDGFRalpha to promote cell migration. Phosphorylated Dock180(Y1811) contributes to activation of Rac1 in human cancers with PDGFRA (show PDGFRA Proteins) amplification.

  9. EGFRvIII (also known as DeltaEGFR and de2-7EGFR), a constitutively active EGFR (show EGFR Proteins) mutant that is frequently co-overexpressed with EGFR (show EGFR Proteins) in human glioblastoma, promotes tumorigenesis through Src (show SRC Proteins) family kinase (SFK)-dependent phosphorylation of Dock180

  10. Dock180 contributes to ovarian carcinogenesis and dissemination

Mouse (Murine) Dedicator of Cytokinesis 1 (DOCK1) interaction partners

  1. Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 (show STAT3 Proteins) coincide with a delay in the initiation of mammary gland involution.

  2. Dock1 and Dock5 are not the important exchange factors regulating Rac (show AKT1 Proteins) activity during the establishment and maintenance of the glomerular barrier

  3. DOCK1-Rac (show AKT1 Proteins) signaling as an HER2 (show ERBB2 Proteins) effector pathway essential for HER2 (show ERBB2 Proteins)-mediated breast cancer progression to metastasis.

  4. The phospholipase D-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.

  5. The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1 (show ELMO1 Proteins), regardless of the presence of the polyproline-containing C-terminal end.

  6. Dock1 has an essential role in embryonic development.

  7. Results indicate that the combination of DOCK2 and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.

Dedicator of Cytokinesis 1 (DOCK1) Protein Profile

Protein Summary

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.

Gene names and symbols associated with DOCK1

  • dedicator of cytokinesis 1 (dock1)
  • dedicator of cytokinesis protein 1 (CpipJ_CPIJ002759)
  • dedicator of cytokinesis 1 (DOCK1)
  • dedicator of cytokinesis 11 (Dock11)
  • dedicator of cytokinesis 11 (DOCK11)
  • Dedicator of cytokinesis protein 11 (doc11)
  • dedicator of cytokinesis 11 (dock11)
  • dedicator of cyto-kinesis 1 (Dock1)
  • dedicator of cytokinesis 1 (Dock1)
  • 9130006G06Rik protein
  • AI854900 protein
  • ced5 protein
  • D630004B07Rik protein
  • DOCK180 protein
  • MGC140073 protein
  • RGD1566072 protein

Protein level used designations for DOCK1

dedicator of cytokinesis protein 1 , dedicator of cytokinesis 1 , dedicator of cytokinesis protein 1-like , dedicator of cytokinesis protein 11 , dedicator of cytokinesis 11 , Dedicator of cytokinesis protein 11 , dedicator of cytokinesis protein 11-like , 180 kDa protein downstream of CRK , DOwnstream of CrK , dedicator of cyto-kinesis 1 , DOCK180

GENE ID SPECIES
572187 Danio rerio
6033953 Culex quinquefasciatus
100055697 Equus caballus
100375196 Saccoglossus kowalevskii
100411936 Callithrix jacchus
100467309 Ailuropoda melanoleuca
313438 Rattus norvegicus
492089 Canis lupus familiaris
537297 Bos taurus
100015415 Monodelphis domestica
100055441 Equus caballus
100081499 Ornithorhynchus anatinus
100354317 Oryctolagus cuniculus
100380692 Salmo salar
100411639 Callithrix jacchus
100457333 Pongo abelii
100477046 Ailuropoda melanoleuca
100498640 Xenopus (Silurana) tropicalis
309081 Rattus norvegicus
1793 Homo sapiens
537203 Bos taurus
330662 Mus musculus
423960 Gallus gallus
486934 Canis lupus familiaris
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