Dedicator of Cytokinesis 2 (DOCK2) ELISA Kits

The protein encoded by DOCK2 belongs to the CDM protein family. Additionally we are shipping DOCK2 Antibodies (50) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse DOCK2 DOCK2 94176 Q8C3J5
Anti-Human DOCK2 DOCK2 1794 Q92608
Anti-Rat DOCK2 DOCK2 360509  
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More ELISA Kits for DOCK2 Interaction Partners

Mouse (Murine) Dedicator of Cytokinesis 2 (DOCK2) interaction partners

  1. findings showed that DOCK2-driven T cell motility was required to detach from pMHC(low) dendritic cells (DCs)and to find rare presenting peptide-MHCs (pMHCs)(high) DCs.

  2. DOCK2 is a potential therapeutic target for novel AML (show RUNX1 ELISA Kits) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 (show FLT3 ELISA Kits) activity and sensitizes FLT3 (show FLT3 ELISA Kits)/ITD leukemic cells to conventional antileukemic agents.

  3. Identify DOCK2 as a novel regulator for smooth muscle cell phenotypic modulation and vascular lesion formation after vascular injury.

  4. DOCK2 is critical for graft facilitating cells to maintain its immunomodulatory function.

  5. together with DOCK5 contributes to chemotaxis, reactive oxygen species production, and extracellular trap formation

  6. the IRF5 (show IRF5 ELISA Kits) (-/-) mice with the DOCK2 mutation have higher serum levels of IgG1 and lower levels of IgG2b, IgG2a/c and IgG3 than IRF5 (show IRF5 ELISA Kits) (-/-) mice without the DOCK2 mutation, suggesting that the DOCK2 mutation confers additional Th2-type effects.

  7. findings reveal a previously unknown, nonredundant role for Elmo1 (show ELMO1 ELISA Kits) in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes.

  8. DOCK2, an atypical guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) for Rac (show AKT1 ELISA Kits), plays a key role in NK cell-mediated cytotoxicity.

  9. in vivo results presented here suggest DOCK2 contributes to amyloid beta plaque burden via regulation of microglial innate immune function and may represent a novel therapeutic target for Alzheimer's disease

  10. Results thus indicate that DOCK2 dimerization is functionally important under the physiological condition where only limited amounts of DOCK2 and Rac (show AKT1 ELISA Kits) are localized to the plasma membrane.

Human Dedicator of Cytokinesis 2 (DOCK2) interaction partners

  1. demonstrated that CPP-conjugation approach is applicable to the development of novel anti-inflammatory drugs based on DOCK2 inhibition by investigating both cellular uptake and bioactivity

  2. DOCK2 is a potential therapeutic target for novel AML (show RUNX1 ELISA Kits) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 (show FLT3 ELISA Kits) activity and sensitizes FLT3 (show FLT3 ELISA Kits)/ITD leukemic cells to conventional antileukemic agents.

  3. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (show CIITA ELISA Kits) (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (show ADAMTS9 ELISA Kits) (rs7631391), DOCK2 (rs77594147), SLC28A1 (show SLC28A1 ELISA Kits) (rs28649017), ARHGAP5 (show ARHGAP5 ELISA Kits) (rs7151991), and CIITA (show CIITA ELISA Kits) (rs45601437) in the Asian comparison.

  4. Autosomal recessive DOCK2 deficiency is a new mendelian disorder with pleiotropic defects of hematopoietic and nonhematopoietic immunity.

  5. findings reveal a previously unknown, nonredundant role for Elmo1 (show ELMO1 ELISA Kits) in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes.

  6. DOCK2 is required for the normal T and B cell migration and signal transduction. (Review)

  7. DOCK2 mutations are associated with esophageal adenocarcinoma.

  8. The C-terminal Pro-rich tail of ELMO1 (show ELMO1 ELISA Kits) winds around the Src (show SRC ELISA Kits)-homology 3 domain of DOCK2 to form an intermolecular 5-helix bundle. The entire regions of both DOCK2 a& ELMO1 (show ELMO1 ELISA Kits) assemble to create a rigid structure required for the DOCK2 & ELMO1 (show ELMO1 ELISA Kits) binding.

  9. Our results show CXCL13 (show CXCL13 ELISA Kits)-mediated PCa (show FLVCR1 ELISA Kits) cell invasion requires Akt (show AKT1 ELISA Kits) and ERK12 activation and suggests a new role for DOCK2 in proliferation of hormone-refractory CXCR5 (show CXCR5 ELISA Kits)-positive PCa (show FLVCR1 ELISA Kits) cells.

  10. prostate cancer cell lines differentially express phosphoinositide-3 kinase (PI3K (show PIK3CA ELISA Kits)) catalytic subunit isoforms and dedicator of cytokinesis 2

DOCK2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection.

Gene names and symbols associated with DOCK2

  • dedicator of cytokinesis 2 (DOCK2) antibody
  • dedicator of cytokinesis 2 (LOC100231624) antibody
  • dedicator of cytokinesis 2 (dock2) antibody
  • dedicator of cyto-kinesis 2 (Dock2) antibody
  • dedicator of cytokinesis 2 (Dock2) antibody
  • AI662014 antibody
  • AW122239 antibody
  • CED-5 antibody
  • Hch antibody
  • MBC antibody

Protein level used designations for DOCK2

dedicator of cytokinesis 2 , dedicator of cytokinesis protein 2-like , dedicator of cytokinesis protein 2 , dedicator of cyto-kinesis 2

GENE ID SPECIES
427612 Gallus gallus
471731 Pan troglodytes
100070446 Equus caballus
100231624 Taeniopygia guttata
100512021 Sus scrofa
100558131 Anolis carolinensis
94176 Mus musculus
1794 Homo sapiens
360509 Rattus norvegicus
489128 Canis lupus familiaris
510083 Bos taurus
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