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anti-Dedicator of Cytokinesis 3 (DOCK3) Antibodies

DOCK3 is specifically expressed in the central nervous system (CNS). Additionally we are shipping DOCK3 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOCK3 208869  
DOCK3 315992  
DOCK3 1795 Q8IZD9
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Top anti-DOCK3 Antibodies at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Reactivity Host Conjugate Application Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 50 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Sheep Un-conjugated IHC 50 μg Log in to see 2 to 3 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB 200 μL Log in to see 9 to 14 Days
$653.03
Details
Human Rabbit Un-conjugated ELISA 200 μL Log in to see 8 to 9 Days
$588.50
Details
Human Rabbit Un-conjugated 50 μL Log in to see 9 to 14 Days
$417.00
Details

DOCK3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) ,


Rat (Rattus)


Human , ,
,

More Antibodies against DOCK3 Interaction Partners

Mouse (Murine) Dedicator of Cytokinesis 3 (DOCK3) interaction partners

  1. Dock3 may be a therapeutic target for demyelinating disorders including optic neuritis.

  2. Overexpression of Dock3 and pharmacological interruption of p38 (show CRK Antibodies) have synergistic effects for both neuroprotection and axon regeneration, thus combined application may be beneficial for the treatment of ONI.

  3. Skeletal muscle-specific (show EIF3K Antibodies) miR (show MLXIP Antibodies)-486 overexpression in Dmdmdx-5Cv animals decreased levels of DOCK3, reduced PTEN (show PTEN Antibodies) expression, and subsequently increased levels of phosphorylated AKT (show AKT1 Antibodies), which resulted in an overall beneficial effect.

  4. These results suggest that Dock3 overexpression prevents glaucomatous retinal degeneration by suppressing both NR2B (show GRIN2B Antibodies)-mediated glutamate (show GRIN1 Antibodies) neurotoxicity and oxidative stress.

  5. The interaction between NR2D (show GRIN2D Antibodies) and Dock3 may have a neuroprotective effect.

  6. MOCA (modifier of cell adhesion), which was originally identified as being a presenilin-and Rac1-binding protein, is a common downstream con (show APP Antibodies)stituent of neuronal death signals

  7. Dock3 plays important roles downstream of brain-derived neurotrophic factor (BDNF (show BDNF Antibodies)) signaling, where it regulates cell polarity and promotes axonal outgrowth by stimulating dual pathways: actin polymerization and microtubule assembly.

  8. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

  9. MOCA may induce cytoskeletal reorganization and changes in cell adhesion by regulating the activity of Rac1.

  10. Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration.

Human Dedicator of Cytokinesis 3 (DOCK3) interaction partners

  1. Results supported that miR (show MLXIP Antibodies)-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines.

  2. MOCA is a key molecule of the Alzheimer disease-relevant neuronal death signals that links the presenilin-mediated death signal with the APP (show APP Antibodies)-mediated death signal at a point between Rac1 or Cdc42 (show CDC42 Antibodies) and ASK1 (show MAP3K5 Antibodies).

  3. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

  4. We report that MOCA modulates cell-cell adhesion and morphology by increasing the accumulation of adherens junction proteins.

  5. MOCA is a novel Wnt (show WNT2 Antibodies) negative regulator and demonstrate that this screening approach can be a rapid means for isolation of new Wnt (show WNT2 Antibodies) regulators.

DOCK3 Antigen Profile

Protein Summary

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins

Gene names and symbols associated with DOCK3

  • dedicator of cytokinesis 3 (DOCK3) antibody
  • similar to dedicator of cytokinesis 3 (LOC561387) antibody
  • dedicator of cytokinesis 3 (dock3) antibody
  • dedicator of cyto-kinesis 3 (Dock3) antibody
  • mKIAA0299 antibody
  • MOCA antibody
  • PBP antibody

Protein level used designations for DOCK3

dedicator of cytokinesis 3 , similar to dedicator of cytokinesis 3 , dedicator of cytokinesis protein 3-like , dedicator of cytokinesis protein 3 , modifier of cell adhesion , presenilin-binding protein

GENE ID SPECIES
415919 Gallus gallus
460402 Pan troglodytes
524692 Bos taurus
561387 Danio rerio
701151 Macaca mulatta
100061408 Equus caballus
100216191 Xenopus (Silurana) tropicalis
100341267 Oryctolagus cuniculus
100411594 Callithrix jacchus
100474164 Ailuropoda melanoleuca
100565563 Anolis carolinensis
208869 Mus musculus
315992 Rattus norvegicus
1795 Homo sapiens
476610 Canis lupus familiaris
100519389 Sus scrofa
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