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DOCK4 is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. Additionally we are shipping DOCK4 Kits (5) and and many more products for this protein.
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Human Monoclonal DOCK4 Primary Antibody for IF, IHC (p) - ABIN564203
Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. in Blood 2008
Dock4 binds to SH3YL1 through the C-terminal proline-rich region.
The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
Rac-DOCK4-actin-binding protein harmonin-activated signaling pathway is possibly involved in regulating actin cytoskeleton organization in stereocilia of the inner ear.
DOCK4 signalling is necessary for lateral filopodial protrusions and tubule remodelling prior to vascular lumen formation
These data identify DOCK4 as a putative 7q gene whose reduced expression can lead to erythroid dysplasia
activator DOCK4 as a key component of the TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) pathway that promotes lung ADC (show ADC Antibodies) cell extravasation and metastasis.
The study found significant associations between autism and a SNP of the DOCK4 gene.
novel epigenetic alterations in myelodysplastic leukocytes and implicate DOCK4 as a pathogenic gene located on the 7q chromosomal region.
Evidence for the involvement of DOCK4 in autism susceptibility was supported by independent replication of association at rs2217262 and the finding of a deletion segregating in a sib-pair family
Data suggest that exonic deletions of DOCK4 may act as a risk factor for reading impairment. Genomic disruption of both DOCK4 and CNTNAP5 genes may have an additive effect and may result in a more severe autism spectrum phenotype.
Taken together, these results suggest that Dock4 plays an important role in the regulation of cell migration through activation of Rac1, and that RhoG (show RHOG Antibodies) is a key upstream regulator for Dock4.
DOCK4 may be regulated by PIP(3) to exert its function
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.
dedicator of cytokinesis 4
, dedicator of cytokinesis protein 4-like
, dedicator of cytokinesis protein 4