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DOCK6 encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Additionally we are shipping and many more products for this protein.
Dock6 may be involved in the development of cystic follicles by suppressing P4 production rather than increasing A4 production in theca cells
this study demonstrates that miR (show MLXIP ELISA Kits)-142-3p is a key regulator of the TGFbeta (show TGFB1 ELISA Kits)-mediated contractile phenotype of VSMCs that acts through inhibiting cell migration through targeting DOCK6.
DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies
A homozygous truncating mutation in dedicator of cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine exchange factor (GEF) known to activate two members of the Rho GTPase family: Cdc42 and Rac1, was identified.
phosphorylation status of Dock6 at Ser(1194) determines whether it promotes axon extension or branching in sensory neurons, revealing interplay between kinase and phosphatase action on a Rho-GEF during axon growth
Dock6 is the GEF (show ARHGEF2 ELISA Kits) specific for both Rac1 and Cdc42 (show CDC42 ELISA Kits) and may be one of physiological regulators of neurite outgrowth.
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2.
dedicator of cytokinesis 7
, dedicator of cytokinesis 6
, dedicator of cytokinesis protein 6