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The protein encoded by DOCK7 is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. Additionally we are shipping and many more products for this protein.
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Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.
These observations suggest that loss of DOCK7 function causes a syndromic form of epileptic encephalopathy by affecting multiple neuronal processes.
Dock7 mediates serum- and HGF (show HGF Antibodies)-induced glioblastoma cell invasion.
DOCK7 functions as an essential and downstream regulator of RAGE (show AGER Antibodies)-mediated cellular migration through the formation of dendritic pseudopodia.
The action of DOCK7 in vivo may involve the coordinated integration of Cdc42 (show CDC42 Antibodies)/Rac (show AKT1 Antibodies) signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (show RASGRF1 Antibodies) (GEF (show SLC2A4RG Antibodies)) complex.
Dock7 functions as an intracellular substrate for ErbB2 (show ERBB2 Antibodies) to promote Schwann cell migration.
DOCK7 acts as a cytoplasmic activator of the ErbB4 (show ERBB4 Antibodies) and is essential for chandelier cell cartridge and bouton development.
DOCK7 interaction with TACC3 (show TACC3 Antibodies) controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
The results of this study identified Dock7 as a novel regulator of Schwann cell differentiation and the onset of myelination both in vitro and in vivo.
Although Dock7 is transcribed at high levels in the developing brain and has been implicated in both axon development and myelination by in vitro studies, we find no requirement for DOCK7 in neurobehavioral function in vivo
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.
dedicator of cytokinesis 7
, dedicator of cytokinesis protein 7
, dedicator of cytokinesis protein 7-like