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Dedicator of Cytokinesis 8 (DOCK8) ELISA Kits

DOCK8 encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Additionally we are shipping DOCK8 Antibodies (36) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human DOCK8 DOCK8 81704 Q8NF50
Anti-Mouse DOCK8 DOCK8 76088 Q8C147
Anti-Rat DOCK8 DOCK8 499337  
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More ELISA Kits for DOCK8 Interaction Partners

Human Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. Letter/Case Report: DOCK8 homozygous mutation leading to primary immune deficiency.

  2. DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels.

  3. CD147 has a role in promoting Src (show SRC ELISA Kits)-dependent activation of Rac1 signaling through STAT3 (show STAT3 ELISA Kits)/DOCK8 during the motility of hepatocellular carcinoma cells

  4. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  5. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

  6. Mutations of DOCK8 in three children, two of whom developed sclerosing cholangitis, are reported.

  7. Hyper-IgE syndromes and atopic dermatitis patients showed different sensitization pattern of serum IgE corresponding to the allergic disease manifestations and Th-cell subset data, suggesting a key role of DOCK8 in the development of food allergy

  8. This is a case of systemic lupus erythematosus with hyper-immunoglobulin E syndrome documented as DOCK8 deficiency.

  9. Biallelic mutations in the DOCK8 gene cause autosomal-recessive hyper-IgE syndrome.

  10. Two novel large deletions, del1-14 exons and del8-18 exons, of DOCK8 have been identified in two siblings with the adaptive immune deficiencies.

Mouse (Murine) Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4 (show CD4 ELISA Kits)(+) T-cell infiltration into HSV-infected skin.

  2. DOCK8 expression in the haematopoietic compartment is required for protective immunity and its deficiency results in drastic reduction of RORgammat+ innate lymphoid cells in the GI tract

  3. conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function

  4. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  5. DOCK8 is required for the development and survival of mature NKT (show CTSL1 ELISA Kits) cells.

  6. DOCK8 regulates interstitial DC migration by controlling Cdc42 (show CDC42 ELISA Kits) activity spatially.

  7. Characterisation of the DOCK8-deficient mouse revealed T-cell lymphopenia, with increased T-cell turnover and decreased survival.

  8. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 (show CD8A ELISA Kits) T cells.

  9. Mutation of the DOCK8 protein in mice has profound effects on humoral immunity with a failure to sustain the antibody response and failure of germinal center B cell persistence. (Review)

  10. Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity.

DOCK8 Antigen Profile

Antigen Summary

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with DOCK8

  • dedicator of cytokinesis 8 (dock8) antibody
  • dedicator of cytokinesis 8 (DOCK8) antibody
  • dedicator of cytokinesis 8 (Dock8) antibody
  • 1200017A24Rik antibody
  • 5830472H07Rik antibody
  • A130095G14Rik antibody
  • AI461977 antibody
  • im:7154406 antibody
  • MRD2 antibody
  • si:dkey-91m11.1 antibody
  • ZIR8 antibody

Protein level used designations for DOCK8

dedicator of cytokinesis 8 , dedicator of cytokinesis protein 8-like , 1200017A24Rik , dedicator of cytokinesis protein 8

GENE ID SPECIES
403040 Danio rerio
427348 Gallus gallus
473156 Pan troglodytes
476333 Canis lupus familiaris
100050677 Equus caballus
100225500 Taeniopygia guttata
100295817 Bos taurus
100354750 Oryctolagus cuniculus
100393468 Callithrix jacchus
100463658 Ailuropoda melanoleuca
100153522 Sus scrofa
100565160 Anolis carolinensis
81704 Homo sapiens
76088 Mus musculus
499337 Rattus norvegicus
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