Dedicator of Cytokinesis 8 (DOCK8) ELISA Kits

DOCK8 encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Additionally we are shipping DOCK8 Antibodies (36) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human DOCK8 DOCK8 81704 Q8NF50
Anti-Mouse DOCK8 DOCK8 76088 Q8C147
Anti-Rat DOCK8 DOCK8 499337  
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More ELISA Kits for DOCK8 Interaction Partners

Human Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. Sequence analysis identified two copies of missense mutation, c.4346C > T, in the coding region of the DOCK8 gene in a family with 3 patients with autosomal recessive Hyper-IgE syndrome.

  2. Our results showed that DOCK8-deficient patients have a profound defect in TH17 differentiation related to decreased STAT3 (show STAT3 ELISA Kits) phosphorylation, translocation to the nucleus, and transcriptional activity

  3. The CD4 (show CD4 ELISA Kits)+ T-cell compartment is greatly altered in the absence of DOCK8. Specifically, DOCK8-deficient patients have increased TH2 cells and defects in TH1 (show TH1L ELISA Kits) and TH17 cell differentiation

  4. comparative study provides a long-term observation of DOCK8- and STAT3-hyper-IgE syndrome patients with regard to clinical and laboratory findings, and assesses the activation and cytokine secretion of lymphocytes after in vitro stimulation

  5. mutations in Chinese patients with hyper-IgE syndrome

  6. Letter/Case Report: DOCK8 homozygous mutation leading to primary immune deficiency.

  7. DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels.

  8. CD147 has a role in promoting Src (show SRC ELISA Kits)-dependent activation of Rac1 signaling through STAT3 (show STAT3 ELISA Kits)/DOCK8 during the motility of hepatocellular carcinoma cells

  9. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  10. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

Mouse (Murine) Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. LRCH1 (show LRCH1 ELISA Kits) as a novel effector to restrain PKCalpha (show PKCa ELISA Kits)-DOCK8-Cdc42 (show CDC42 ELISA Kits) module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).

  2. found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain

  3. DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4 (show CD4 ELISA Kits)(+) T-cell infiltration into HSV-infected skin.

  4. DOCK8 expression in the haematopoietic compartment is required for protective immunity and its deficiency results in drastic reduction of RORgammat+ innate lymphoid cells in the GI tract

  5. conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function

  6. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  7. DOCK8 is required for the development and survival of mature NKT (show CTSL1 ELISA Kits) cells.

  8. DOCK8 regulates interstitial DC migration by controlling Cdc42 (show CDC42 ELISA Kits) activity spatially.

  9. Characterisation of the DOCK8-deficient mouse revealed T-cell lymphopenia, with increased T-cell turnover and decreased survival.

  10. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 (show CD8A ELISA Kits) T cells.

DOCK8 Antigen Profile

Antigen Summary

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with DOCK8

  • dedicator of cytokinesis 8 (dock8) antibody
  • dedicator of cytokinesis 8 (DOCK8) antibody
  • dedicator of cytokinesis 8 (Dock8) antibody
  • 1200017A24Rik antibody
  • 5830472H07Rik antibody
  • A130095G14Rik antibody
  • AI461977 antibody
  • im:7154406 antibody
  • MRD2 antibody
  • si:dkey-91m11.1 antibody
  • ZIR8 antibody

Protein level used designations for DOCK8

dedicator of cytokinesis 8 , dedicator of cytokinesis protein 8-like , 1200017A24Rik , dedicator of cytokinesis protein 8

403040 Danio rerio
427348 Gallus gallus
473156 Pan troglodytes
476333 Canis lupus familiaris
100050677 Equus caballus
100225500 Taeniopygia guttata
100295817 Bos taurus
100354750 Oryctolagus cuniculus
100393468 Callithrix jacchus
100463658 Ailuropoda melanoleuca
100153522 Sus scrofa
100565160 Anolis carolinensis
81704 Homo sapiens
76088 Mus musculus
499337 Rattus norvegicus
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