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novel thyroid transcript negatively regulated by thyroid stimulating hormone [RGD, Feb 2006].. Additionally we are shipping and many more products for this protein.
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Human Polyclonal DOCK9 Primary Antibody for ICC, IF - ABIN153062
Sakabe, Asai, Iijima, Maruyama: Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. in Immunity & ageing : I & A 2012
Show all 2 references for ABIN153062
c.2262A>C substitution in DOCK9 leads to a splicing aberration. However, because the mutation effect was observed in vitro, a definitive relationship between DOCK9 and KTCN (show VSX1 Antibodies) phenotype could not be established.
Studies indicate that that many of the mechanistic principles of the exchange process are conserved in the DOCK9-catalyzed reaction.
Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42 (show CDC42 Antibodies)
DOCK9 contributes to both risk and increased illness severity in bipolar disorder.
novel functions for the N-terminal region of zizimin1.
DOCK2 (show DOCK2 Antibodies) and DOCK9 specifically recognize Rac2 (show RAC2 Antibodies) and Cdc42 (show CDC42 Antibodies) through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac (show AKT1 Antibodies)-specific DHR-2 GEFs
interaction between Smad2 (show SMAD2 Antibodies)/3 and the Cdc42 (show CDC42 Antibodies) guanine nucleotide exchange factor (show RASGRF1 Antibodies), Zizimin1, in response to TGF-beta1 (show TGFB1 Antibodies)
through structural analysis of DOCK9-Cdc42 (show CDC42 Antibodies) complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP (show AK3 Antibodies)-bound Cdc42 (show CDC42 Antibodies)
Thus, these results suggest that Zizimin1 plays an important role in dendrite growth in hippocampal neurons through activation of Cdc42 (show CDC42 Antibodies).
novel thyroid transcript negatively regulated by thyroid stimulating hormone
dedicator of cytokinesis 9
, dedicator of cytokinesis protein 9
, Dedicator of cytokinesis protein 9
, dedicator of cytokinesis protein 9-like
, cdc42 guanine nucleotide exchange factor zizimin-1
, Thyroid regulating