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anti-Defensin, alpha 5, Paneth Cell-Specific (DEFA5) Antibodies

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. Additionally we are shipping Defensin, alpha 5, Paneth Cell-Specific Kits (36) and Defensin, alpha 5, Paneth Cell-Specific Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DEFA5 290856  
DEFA5 1670 Q01523
DEFA5 13239  
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Top anti-Defensin, alpha 5, Paneth Cell-Specific Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated DB, ICC, FACS, IF, IHC (p), IHC, ELISA, WB Human skeletal muscle myocytes showing moderate nuclear and faint cytoplasmic staining using ABIN258712. Flow Cytometry: Defensin alpha 5 Antibody (8C8) [ABIN2587122] - Intracellular flow cytometric staining of 1 x 10^6 MCF-7 cells using Defensin alpha 5 antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: Defensin alpha 5 Antibody [NBP1-84282] - Staining of human small intestine shows strong cytoplasmic positivity in Paneth cells. Immunohistochemistry-Paraffin: Defensin alpha 5 Antibody [NBP1-84282] - Staining of human nasopharynx shows cytoplasmic and membranous positivity in respiratory epithelial cells. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 8 to 10 Days
$566.50
Details
Human Mouse Un-conjugated IF, IHC (p), WB Human Small Intestine (formalin-fixed, paraffin-embedded) stained with DEFA5 antibody ABIN396940 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 200 μg Log in to see 9 to 11 Days
$387.20
Details
Human Mouse Un-conjugated IF, IHC (p), WB 100 μL Log in to see 5 to 6 Days
$506.80
Details
Human Rabbit FITC ELISA, WB   50 μL Log in to see 8 to 10 Days
$610.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$365.20
Details
Human Mouse Alexa Fluor 405 ELISA, FACS, ICC, IF, IHC, IHC (p), WB   0.1 mL Log in to see 5 to 7 Days
$500.06
Details
Human Mouse Alexa Fluor 488 ELISA, FACS, ICC, IF, IHC, IHC (p), WB   0.1 mL Log in to see 5 to 7 Days
$500.06
Details

DEFA5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , , ,
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Mouse (Murine)


Top referenced anti-Defensin, alpha 5, Paneth Cell-Specific Antibodies

  1. Human Monoclonal DEFA5 Primary Antibody for DB, ICC - ABIN258712 : Wehkamp, Salzman, Porter, Nuding, Weichenthal, Petras, Shen, Schaeffeler, Schwab, Linzmeier, Feathers, Chu, Lima, Fellermann, Ganz, Stange, Bevins: Reduced Paneth cell alpha-defensins in ileal Crohn's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 6 references for ABIN258712

  2. Human Polyclonal DEFA5 Primary Antibody for IHC, IHC (p) - ABIN4304804 : Lee, Nam, Park, Kim, Lafleur, Aburatani, Yang, Kim, Goldenring: Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. in Gastroenterology 2010 (PubMed)

More Antibodies against Defensin, alpha 5, Paneth Cell-Specific Interaction Partners

Human Defensin, alpha 5, Paneth Cell-Specific (DEFA5) interaction partners

  1. a moderately active linear peptide derived from the alpha-defensin (show DEF Antibodies) HD5 can be engineered to enhance antimicrobial activity almost comparable to the native peptide.

  2. The study used ion mobility coupled to mass spectrometry to track the structural changes in HD-5 upon disulfide bond reduction.

  3. The study reports the screening of human defensin 5 against the Keio Collection of E. coli strains and shows how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.

  4. Authors show that although NOD2 (show NOD2 Antibodies) by itself can slightly up-regulate expression of HD5 and HD6 (show DEFA6 Antibodies), it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK (show MAPK1 Antibodies) pathway.

  5. These data support a model in which HD5 prevents furin (show FURIN Antibodies) from accessing human papillomavirus 16 L2 by occluding the furin (show FURIN Antibodies) cleavage site via direct binding to the viral capsid.

  6. Enteric alpha-defensin (show DEF Antibodies) HD5 and beta-defensin (show DEFB1 Antibodies) hBD2 (show DEFB4 Antibodies) shared similar toxin-unfolding effects with HNP1 (show DEFA1 Antibodies), albeit to different degrees.

  7. our results highlight the potential contribution of altered alpha-defensin (show DEF Antibodies) HD-5 expression in the formation of a viral/tumour-permissive environment in high-risk HPV infection and progression to cancer of the uterine cervix

  8. DEFA5 displays antimicrobial activity against E. coli, E. aerogenes, B. cereus, and S. aureus.

  9. Data indicate that cellular effects of defensin 5 involve interactions with the extra-cellular domain of tumor necrosis Factor (show TNF Antibodies) 1.

  10. Anti-HIV activity of human defensin 5 in primary CD4 (show CD4 Antibodies)+ T cells under serum-deprived conditions is a consequence of defensin (show DEF Antibodies)-mediated cytotoxicity.

Mouse (Murine) Defensin, alpha 5, Paneth Cell-Specific (DEFA5) interaction partners

  1. Data show that DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17 (show IL17A Antibodies))-producing lamina propria T cells.

Defensin, alpha 5, Paneth Cell-Specific (DEFA5) Antigen Profile

Protein Summary

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene names and symbols associated with DEFA5

  • defensin, alpha 5, Paneth cell-specific (DEFA5) antibody
  • alpha-defensin 1A (MNP1A) antibody
  • defensin alpha 24 (Defa24) antibody
  • defensin, alpha 5, Paneth cell-specific (Defa5) antibody
  • defensin, alpha, 5 (Defa5) antibody
  • DEF5 antibody
  • Defa antibody
  • DEFA1 antibody
  • DEFA5 antibody
  • Defa29 antibody
  • Defcr4 antibody
  • Defcr5 antibody
  • Defcr24 antibody
  • Defcr29 antibody
  • defensin-5 antibody
  • defensin 6 antibody
  • defensin 7 antibody
  • HD-5 antibody
  • Rd5 antibody

Protein level used designations for DEFA5

alpha-defensin 5, Paneth cell-specific , Paneth cell-specific alpha-defensin 5 , Neutrophil defensin 1 , Neutrophil defensin 3 , RMAD-1 , RMAD-3 , RMAD-8 , neutrophil defensin 8 , RD-5 , alpha-defensin, 24 , defensin 5 , defensin related cryptdin 24 , defensin related cryptdin 4 , defensin, alpha, 24 , enteric defensin alpha 5 , HD5(20-94) , defensin, alpha 5, preproprotein , defensin-5 , defensin NP-2 , neutrophil antibiotic peptide NP-1 , neutrophil antibiotic peptide NP-2 , neutrophil defensin 1 , neutrophil defensin 2 , ratNP-1 , ratNP-2 , defensin, alpha 1 , alpha-defensin 5 , defensin, alpha, 29 , defensin-related cryptdin-5

GENE ID SPECIES
100307028 Equus caballus
574196 Macaca mulatta
290856 Rattus norvegicus
1670 Homo sapiens
286995 Rattus norvegicus
463972 Pan troglodytes
13239 Mus musculus
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