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Deformed Epidermal Autoregulatory Factor 1 (Drosophila) Proteins (DEAF1)

Transcription factor that binds the homeotic Deformed (Dfd) response element. Additionally we are shipping DEAF1 Antibodies (92) and DEAF1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DEAF1 100294411  
DEAF1 83632 O88450
DEAF1 54006 Q9Z1T5
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Top DEAF1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,620.83
Details

DEAF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1) interaction partners

  1. effects of loss or gain of DEAF-1 function on Drosophila development

  2. DEAF-1 is a regulator of Drosophila immunity; it activates the expression of Mtk and Drs (show DARS Proteins) promoter.

Human Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1) interaction partners

  1. an autosomal recessive splice acceptor mutation in DEAF1 (c.997+4A>C, p.G292Pfs*) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the patients with epilepsy and extrapyramidal symptoms

  2. Data show that deformed epidermal autoregulatory factor-1 (DEAF1) was located in the nucleus under the fluorescence microscope.

  3. These data suggest that during the progression of type 1 diabetes, inflammation and hyperglycemia mediate the splicing of DEAF1 and loss of peripheral tissue antigen expression.

  4. This study indicates, for the first time, a hereditary role of DEAF1 in white matter abnormalities, microcephaly and syndromic intellectual disability.

  5. these results demonstrate that mutations in DEAF1 cause ID and behavioral problems, most likely as a result of impaired transcriptional regulation by DEAF1.

  6. Pellino1 interacts with the transcription facto (show IRF3 Proteins)r Deforme (show IRF7 Proteins)d Epidermal Autoregulatory Factor 1 (DEAF1).

  7. Non-genomic downregulation of 5-HT1A receptor (show HTR1A Proteins) by 17beta-estradiol does not involve NUDR and Freud-1 (show CC2D1A Proteins) proteins.

  8. DEAF1 can interact with the DNA-PK complex through interactions of its DNA binding domain with the carboxy-terminal region of Ku70 (show XRCC6 Proteins) that contains the Bax (show BAX Proteins) binding domain, and that DEAF1 is a potential substrate for DNA-PK.

  9. Data identify DEAF1 as an interactor and in vitro substrate of GSK3A (show GSK3a Proteins) and GSK3B that interacts with the phosphatidylinositol 3-kinase-mammalian target of rapamycin (show FRAP1 Proteins) pathway.

  10. These results suggest that transcription factors such as Aire and Deaf1, which exert global transcriptional regulatory functions, may play important roles in self-renewal of ESCs and maintaining ESC in a transcriptionally hyperactive state.

Mouse (Murine) Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1) interaction partners

  1. These data suggest that during the progression of type 1 diabetes, inflammation and hyperglycemia mediate the splicing of DEAF1 and loss of peripheral tissue antigen expression.

  2. DEAF1 binds to the IFNbeta promoter and to IRF3 (show IRF3 Proteins) and IRF7 (show IRF7 Proteins), that it is required for the transcription of the IFNbeta gene and IFNbeta secretion

  3. reduced DEAF1 function, and subsequent loss of Eif4g3 transcription may affect peripheral tissue antigen (PTA) expression in LNSCs and contribute to the pathology of T1D.

  4. LMO4 (show LMO4 Proteins) modulates the activity of the DEAF NES (show NES Proteins), causing nuclear accumulation of a construct containing the LMO4 (show LMO4 Proteins)-interaction region of DEAF1.

  5. Reduced raphe 5-HT (show DDC Proteins) content in Deaf-1(-/-) mice indicate its importance in regulation of 5-HT1A (show HTR1A Proteins) gene expression and the role of the 5-HT1A (show HTR1A Proteins) G(-1019) allele in reducing serotonergic neurotransmission by derepression of 5-HT1A (show HTR1A Proteins) autoreceptors.

  6. These results suggest that transcription factors such as Aire and Deaf1, which exert global transcriptional regulatory functions, may play important roles in self-renewal of ESCs and maintaining ESC in a transcriptionally hyperactive state.

  7. Data indicate an important role for LMO4 (show LMO4 Proteins) and Deaf-1 in pathways affecting neural tube closure and skeletal patterning, most likely reflecting their presence in a functional complex in vivo.

  8. Lower peripheral tissue antigens (PTA (show PTCRA Proteins)) expression resulting from the alternative splicing of DEAF1 may contribute to the pathogenesis of type 1 diabetes.

DEAF1 Protein Profile

Protein Summary

Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd.

Gene names and symbols associated with DEAF1

  • Deformed epidermal autoregulatory factor-1 (Deaf1)
  • DEAF1 transcription factor (DEAF1)
  • zgc:194895 (zgc:194895)
  • deformed epidermal autoregulatory factor 1 homolog (deaf-1)
  • deformed epidermal autoregulatory factor 1 homolog (LOC100294411)
  • deformed epidermal autoregulatory factor 1 (Drosophila) (DEAF1)
  • deformed epidermal autoregulatory factor 1 homolog (LOC100431538)
  • deformed epidermal autoregulatory factor 1 homolog (LOC100462625)
  • deformed epidermal autoregulatory factor 1 homolog (LOC100477361)
  • deformed epidermal autoregulatory factor 1 homolog (LOC100510366)
  • deformed epidermal autoregulatory factor 1 homolog (LOC100512152)
  • deformed epidermal autoregulatory factor 1 (DEAF1)
  • deformed epidermal autoregulatory factor 1 (deaf1)
  • DEAF1 transcription factor (Deaf1)
  • deformed epidermal autoregulatory factor 1 (Drosophila) (Deaf1)
  • AU042387 protein
  • C230009B13Rik protein
  • CG8567 protein
  • Deaf-1 protein
  • deaf1 protein
  • Dmel\\CG8567 protein
  • l(3)76BDv protein
  • MYND5 protein
  • NUDR protein
  • SPN protein
  • ZMYND5 protein

Protein level used designations for DEAF1

CG8567-PA , CG8567-PB , CG8567-PC , CG8567-PD , CG8567-PE , Deaf1-PA , Deaf1-PB , Deaf1-PC , Deaf1-PD , Deaf1-PE , deaf-1 , deformed epidermal autoregulatory factor-1 , deformed epidermal autoregulatory factor 1 homolog , deformed epidermal autoregulatory factor 1 (Drosophila) , deformed epidermal autoregulatory factor 1 homolog-like , deformed epidermal autoregulatory factor 1 , suppressin , nuclear DEAF-1-related transcriptional regulator , zinc finger MYND domain-containing protein 5 , DEAF-1 related transcriptional regulator (NUDR) , NUDR , DEAF-1 related transcriptional regulator , nuclear DEAF-1 related transcriptional regulator , zinc finger MYND domain containing 5

GENE ID SPECIES
40164 Drosophila melanogaster
509260 Bos taurus
563776 Danio rerio
779003 Ciona intestinalis
100294411 Homo sapiens
100404683 Callithrix jacchus
100431538 Pongo abelii
100462625 Pongo abelii
100477361 Ailuropoda melanoleuca
100510366 Homo sapiens
100512152 Sus scrofa
720821 Macaca mulatta
100137100 Xenopus (Silurana) tropicalis
100596296 Nomascus leucogenys
10522 Homo sapiens
83632 Rattus norvegicus
423017 Gallus gallus
483409 Canis lupus familiaris
54006 Mus musculus
373853 Pan troglodytes
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