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DEGS2 encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. Additionally we are shipping Degenerative Spermatocyte Homolog 2, Lipid Desaturase (Drosophila) Antibodies (24) and Degenerative Spermatocyte Homolog 2, Lipid Desaturase (Drosophila) Kits (2) and many more products for this protein.
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overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia
DES2 is the dihydroceramide C-4 hydroxylase responsible for the biosynthesis of enriched phytosphingoglycolipids in the microvillous membranes of intestinal epithelial cells
the hydroxylation of dihydroceramide: sphinganine C-4 requires complex formation between Des2 and mb5 via their membrane-spanning domains and electron transfer from NADH to the substrate via the reduction of mb5 by b5R (show CYB5R3 Proteins)
Findings demonstrate that a SNP showing genome-wide association study significant association with cognition in schizophrenia is also associated with regulation of DEGS2 expression, implicating a molecular mechanism for the clinical association.
DES2 was identified and its up-regulation followed during keratinocyte differentiation.
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.
sphingolipid delta 4 desaturase/C-4 hydroxylase
, sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
, degenerative spermatocyte homolog 2, lipid desaturase
, sphingolipid C4-hydroxylase/delta 4-desaturase
, sphingolipid delta(4)-desaturase 2