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The protein encoded by DHDDS catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Additionally we are shipping Dehydrodolichyl Diphosphate Synthase Antibodies (25) and Dehydrodolichyl Diphosphate Synthase Kits (2) and many more products for this protein.
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isolation and characterization of dehydrodolichyl diphosphate synthase and determination of its mRNA abundance in two different strains, STEELHEAD and BORN
These results demonstrate that suppression of DHDDS expression in zebrafish leads to the loss of photoreceptor outer segments and visual function.
findings show that eukaryotic cis-PT is composed of the NgBR and hCIT subunits. The strong conservation of the RXG motif among NgBR orthologs indicates that this subunit is critical for the synthesis of polyprenol diphosphates and cellular function.
We identified the MAK (show MAK Proteins) and DHDDS mutations homozygously in only 2.1% and 0.8%, respectively, of patients of mixed ethnicity, but in 25.7% and 8.6%, respectively, of cases reporting Jewish ancestry
A single-nucleotide mutation in the gene that encodes DHDDS has been identified by whole exome sequencing as the cause of the non-syndromic recessive retinitis pigmentosa (RP) in a family of Ashkenazi Jewish origin.
A missense mutation in DHDDS is associated with autosomal-recessive retinitis pigmentosa.
A variant in DHDDS is associated with retinitis pigmentosa.
identification and characterization; overexpression of CIT (show CIT Proteins) in CHO cells results in a modest increase in cis-isoprenyltransferase activity associated with microsomal fractions
molecular cloning; results suggest a regulatory relationship between CPT (show CHPT1 Proteins) activity and dolichol biosynthesis, and may implicate CPT (show CHPT1 Proteins) in the levels of dolichol-oligosaccharide intermediate biosynthesis
The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
dehydrodolichyl diphosphate synthase
, cis-prenyl transferase
, dedol-PP synthase
, epididymis tissue protein Li 189m