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Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009].. Additionally we are shipping Dehydrogenase/reductase (SDR Family) Member 3 Antibodies (52) and many more products for this protein.
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dhrs3 participates in atRA metabolism by reducing atRAL levels and is required for proper anteroposterior axis formation, neuroectoderm patterning, and somitogenesis.
Data show that dhrs3 was activated at the onset of gastrulation, and remained highly expressed at later stages of embryonic development.
Dhrs3a is thus an retinoic acid (RA)-induced feedback inhibitor of RA biosynthesis.
the bifunctional nature of retinoid oxidoreductase (show TXNRD1 Proteins) complex provides the RA-based signaling system with robustness by safeguarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 (show RDH10 Proteins) and DHRS3.
Data indicate that retinaldehyde reductase (DHRS3) requires retinol dehydrogenase 10 (RDH10 (show RDH10 Proteins)) for full enzymatic activity and, in turn, activates RDH10 (show RDH10 Proteins).
p53 (show TP53 Proteins)-Inducible DHRS3 is an endoplasmic reticulum protein (show PDIA3 Proteins) associated with lipid droplet accumulation.
The retSDR1 is identified as novel transcriptional target of the p53 (show TP53 Proteins) family and not transactivated by EEC syndrome-specific mutations of TAp63gamma.
CST6 (show CST6 Proteins), CXCL14 (show CXCL14 Proteins), DHRS3, and SPP1 (show SPP1 Proteins) are regulated by BRAF (show BRAF Proteins) signaling and may play a role in papillary thyroid carcinoma pathogenesis
Reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development.
Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000
short-chain dehydrogenase/reductase 3
, dehydrogenase/reductase 3
, dehydrogenase/reductase (SDR family) member 3
, retinal short-chain dehydrogenase/reductase 1
, short chain dehydrogenase/reductase family 16C, member 1
, short-chain dehydrogenase/reductase 1
, retinal dehydrogenase/reductase family member 3