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Deiodinase, Iodothyronine, Type I Proteins (DIO1)

The protein encoded by DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. Additionally we are shipping DIO1 Antibodies (28) and DIO1 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DIO1 1733 P49895
DIO1 13370 Q61153
DIO1 25430 P24389
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Top DIO1 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
Yeast Killifish (Fundulus) His tag   1 mg Log in to see 56 to 66 Days
Yeast REACT_Cichlidae His tag   1 mg Log in to see 56 to 66 Days

DIO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Deiodinase, Iodothyronine, Type I (DIO1) Interaction Partners

Human Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

  1. All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 (show DIDO1 Proteins) function in HepG2 cells.

  2. Thyroid hormone (show PTH Proteins) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Proteins) exposure.

  3. The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.

  4. [review] Deiodinase type 1 polymorphisms particularly show moderate-to-strong relationships with thyroid hormone (show PTH Proteins) parameters, insulin (show INS Proteins)-like growth factor (IGF)1 (show IGF1 Proteins) protein production, and risk for depression.

  5. a new mechanism of posttranscriptional regulation of DIO1 (show DIDO1 Proteins) and show deregulation of DIO1 (show DIDO1 Proteins) expression in pituitary adenoma, possibly resulting from disturbed expression of SF2/ASF (show SRSF1 Proteins).

  6. Data indicate that type 1 deiodinase is subject to catalysis-induced loss of activity.

  7. investigation of DIO1 (show DIDO1 Proteins) and DIO2 (show DIO2 Proteins) activities in 66 thyroid tissue samples from follicular thyroid adenoma, toxic diffuse goiter, nontoxic multinodular goiter, papillary thyroid carcinoma, and surrounding normal tissues

  8. Short interfering RNA-mediated knockdown of FOXA1 (show FOXA1 Proteins) decreased the expression of DIO1 (show DIDO1 Proteins) mRNA, but knockdown of both FOXA1 (show FOXA1 Proteins) and FOXA2 (show FOXA2 Proteins) restored it.

  9. a novel miRNA-mediated regulatory mechanism of Type 1 iodothyronine deiodinase expression in clear cell Renal Cell Carcinoma (show MOK Proteins)

  10. we report that SNP at the DIO1 (show DIDO1 Proteins) variant rs11206244 is associated with lifetime major depression in White females in high-risk cohorts.

Mouse (Murine) Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

  1. Systemic changes in thyroid hormone (show PTH Proteins) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type4 and type3 in tissues and their enhanced metabolism by deiodinase D3.

  2. Results demonstrate changes in D1 activity in white adipose tissue under conditions of changing adiposity, and a stimulatory effect of leptin (show LEP Proteins) on D1 activity in the tissue.

  3. A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis (show S100A8 Proteins)

  4. The type 1 deiodinase (D1) is an important source of Triiodothyronine in the euthyroid state.

  5. HNF4alpha (show HNF4A Proteins) regulates thyroid hormone (show PTH Proteins) homeostasis through transcriptional regulation of the Dio1 gene with GATA4 (show GATA4 Proteins) and KLF9 (show KLF9 Proteins)

Pig (Porcine) Deiodinase, Iodothyronine, Type I (DIO1) interaction partners

DIO1 Protein Profile

Protein Summary

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.

Gene names and symbols associated with DIO1

  • deiodinase, iodothyronine, type I (LOC100231867)
  • deiodinase, iodothyronine, type 1 (dio1)
  • deiodinase, iodothyronine, type I (DIO1)
  • deiodinase, iodothyronine, type I (Dio1)
  • 5DI protein
  • D1 protein
  • DIOI protein
  • ITDI1 protein
  • TXDI1 protein

Protein level used designations for DIO1

5DI , DIOI , deiodinase, iodothyronine, type I , type 1 DI , type 1 deiodinase , type I iodothyronine deiodinase , type-I 5'-deiodinase , thyroxine deiodinase type I (selenoprotein) , thyroxine deiodinase, type I , thyroxine deiodinase type 1 , Type 1 DI , Type-I 5'-deiodinase

100231867 Taeniopygia guttata
733447 Xenopus laevis
1733 Homo sapiens
13370 Mus musculus
25430 Rattus norvegicus
403635 Canis lupus familiaris
395940 Gallus gallus
414380 Sus scrofa
100101570 Oryctolagus cuniculus
493798 Felis catus
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