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The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. Additionally we are shipping DIO3 Kits (16) and DIO3 Proteins (15) and many more products for this protein.
Showing 10 out of 94 products:
Hamster Polyclonal DIO3 Primary Antibody for FACS, IHC (p) - ABIN446380
Kalló, Mohácsik, Vida, Zeöld, Bardóczi, Zavacki, Farkas, Kádár, Hrabovszky, Arrojo E Drigo, Dong, Barna, Palkovits, Borsay, Herczeg, Lechan, Bianco, Liposits, Fekete, Gereben: A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. in PLoS ONE 2012
Show all 8 references for ABIN446380
Hamster Polyclonal DIO3 Primary Antibody for ICC, IF - ABIN410067
Freitas, Gereben, Castillo, Kalló, Zeöld, Egri, Liposits, Zavacki, Maciel, Jo, Singru, Sanchez, Lechan, Bianco: Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. in The Journal of clinical investigation 2010
Show all 6 references for ABIN410067
Human Polyclonal DIO3 Primary Antibody for EIA, IHC (p) - ABIN951914
Bessho, Etani, Ichimori, Miyoshi, Namba, Yoneda, Ooue, Chihara, Morii, Aoki, Murakami, Mushiake, Ozono: Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism. in European journal of pediatrics 2009
Show all 5 references for ABIN951914
Hamster Polyclonal DIO3 Primary Antibody for IHC (p), WB - ABIN446381
Jo, Kalló, Bardóczi, Arrojo e Drigo, Zeöld, Liposits, Oliva, Lemmon, Bixby, Gereben, Bianco: Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Show all 4 references for ABIN446381
Human Polyclonal DIO3 Primary Antibody for IHC (p), WB - ABIN653482
Aerts, Arrojo E Drigo, Van Herck, Sammels, Mirebeau-Prunier, Gereben, Zeöld, Harney, Huang, Mulcahey, Van der Geyten, Van den Bergh, Arckens, Darras, Zavacki: Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells. in Endocrinology 2009
Show all 3 references for ABIN653482
The brain-specific (show CALY Antibodies) miR (show MLXIP Antibodies)-379/miR (show MLXIP Antibodies)-410 gene cluster at the imprinted Dlk1 (show DLK1 Antibodies)-Dio3 domain is implicated in several aspects of brain development and function.
DNA methylation (show HELLS Antibodies) regulates genomic imprinted DLK1 (show DLK1 Antibodies)-Dio3 miRNAs in autoimmune lupus
identify the molecular regulators involved in the recruitment of AFF3 (show AFF3 Antibodies) to gDMRs and provide mechanistic insight into the requirement of AFF3 (show AFF3 Antibodies) at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1 (show DLK1 Antibodies)-Dio3 locus
Dppa3 (show DPPA3 Antibodies) has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Antibodies) cells and maintenance of Dlk1 (show DLK1 Antibodies)-Dio3 imprinting
Gtl2((-/+)) teratomas have decreased expression of 28 miRNAs encoded by the Dlk1 (show DLK1 Antibodies)-Dio3 domain
This study provides the spatiotemporal expression and dynamic changes of lncRNAs from Dlk1-Dio3 imprinted region in mouse preimplantation stage embryos and offers insight into the potential mechanisms responsible for Gtl2 activation.
The existence of unidentified epigenetic determinants of tissue-specific Dio3 imprinting.
DNA methylation (show HELLS Antibodies) dynamics of a maternally methylated DMR (show WDR20 Antibodies) in the mouse Dlk1 (show DLK1 Antibodies)-Dio3 domain
Upregulation of Prdm14 (show PRDM14 Antibodies) results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1 (show DLK1 Antibodies)-Dio3 locus.
These results suggest that a cAMP-PKA-mediated pathway participates in Glucagon-like peptide-1 (show GCG Antibodies) stimulated Dio3 expression in MIN6 cells.
No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.
MAPK (show MAPK1 Antibodies) and SHH (show SHH Antibodies) pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma
Thyroid hormone (show PTH Antibodies) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Antibodies) exposure.
the microRNA cluster at the Dlk1 (show DLK1 Antibodies)-Dio3 locus is upregulated in lung adenocarcinoma
[review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone (show PTH Antibodies) parameters.
Overall, the data suggest that active expression of the DLK1 (show DLK1 Antibodies)-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.
the imprinted DLK1 (show DLK1 Antibodies)-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome
Data indicate that Na+/I- symporter (show SLC5A5 Antibodies) and type 3 iodothyronine deiodinase genes are expressed in term placenta and amniotic membrane.
Reviewed are the microRNAs within the DLK1 (show DLK1 Antibodies)-DIO3 genomic region, their role in controlling tissue homeostasis and in the pathogenesis of some human diseases, mostly cancer, when aberrantly expressed. [review]
Deiodinase iodothyronine type III activity was increased in all papillary thyroid carcinomas as compared with that in adjacent thyroid tissue, parallel with ~ 5 times increase in deiodinase iodothyronine type III mRNA levels.
D3 expression in perinatal pancreatic beta-cells prevents untimely exposure to thyroid hormone (show PTH Antibodies), the absence of which leads to impaired beta-cell function and subsequently insulin (show INS Antibodies) secretion and glucose homeostasis
The imprinted gene DIO3 is a candidate gene for litter size in pigs
DIO3 gene polymorphism was significantly associated with almost all fat deposition and carcass traits.
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
type III iodothyronine deiodinase
, Type 3 DI
, Type-III 5'-deiodinase
, type 3 iodothyronine deiodinase
, deiodinase, iodothyronine, type III
, gene 15
, type 3 deiodinase
, iodothyronine 5-deiodinase type III
, type 3 DI
, type-III 5'-deiodinase
, deiodinase, iodothyronine, type 3
, iodothyronine deiodinase, placental type
, thyroxine deiodinase type III (selenoprotein)
, type 3 iodothyronine selenodeiodinase
, type-III 5' deiodinase
, iodothyronine deiodinase type III