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Deleted in Azoospermia-Like Proteins (DAZL)

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. Additionally we are shipping DAZL Antibodies (61) and DAZL Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DAZL 1618 Q92904
DAZL 13164 Q64368
Rat DAZL DAZL 680486  
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Top DAZL Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,575.83
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Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,753.67
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Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,753.67
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Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,762.83
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Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,781.17
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Yeast Callithrix jacchus His tag   1 mg Log in to see 56 to 66 Days
$2,784.83
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DAZL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Deleted in Azoospermia-Like (DAZL) Interaction Partners

Pig (Porcine) Deleted in Azoospermia-Like (DAZL) interaction partners

  1. DAZL c.570+385 A>G and DAZL c.735+150 C>A locus were the potential molecular markers for improving the sperm quality traits in pigs.

  2. DAZL enhances in vitro derived porcine germ cell formation and meiosis.

  3. MK is able to maintain a proliferative PGC (show PGC Proteins) phenotype mediated by the suppression of DAZL in early germ cells

  4. cloning & characterization of the Deleted in AZoospermia Like (pDAZL) gene; pDAZL gene might be a good candidate gene of litter size trait & provides some marker information for marker-assisted selection.

  5. DNA methylation (show HELLS Proteins) may suppress DAZL expression in somatic cells by interfering with Sp1 (show SP1 Proteins) binding.

  6. The porcine DAZL coding sequence is highly homologous to those reported for the human and mouse cDNAs, and DAZL expression increases during oocyte maturation.

Human Deleted in Azoospermia-Like (DAZL) interaction partners

  1. analysis demonstrated that SNP260 of DAZL did not contribute to oligo/azoospermia while SNP386 was correlated to male infertility

  2. Neither the A260G nor the A386G polymorphism of DAZL appeared to be involved in male infertility.

  3. demonstrate that Boll (show BOLL Proteins) is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl

  4. Abnormal DNA methylation (show HELLS Proteins) of the DAZL promoter might represent an epigenetic marker of male infertility.

  5. Amniotic fluid-derived stem cells (AFSc) seem to express Nodal, Nanog (show NANOG Proteins) and DAZL and it speculated that the regulation of self-renewal in AFSc could be similar as in human embryonic stem cells.

  6. The A260G and A386G polymorphisms of the DAZL gene are not correlated with astheno-teratozoospermia-induced male infertility in the Han Chinese population.

  7. study identified the core promoter of the DAZL gene; also provided preliminary evidence for the role of a novel SNP of the DAZL gene promoter in spermatogenic failure

  8. overexpression of VASA (show DDX4 Proteins) and or DAZL, in both embryonic and induced pluripotent stem cells promoted differentiation into primordial germ cells, and maturation and progression through meiosis was enhanced.

  9. results showed no significant differences in the frequency of DAZL AG (P = 0.58) and MTHFR (show MTHFR Proteins) CT (P = 0.44) between oligozoospermic infertile men and controls

  10. These results suggest that incorrect epigenetic marks in germline gene DAZL may be correlated with male gametogenic defects.

Mouse (Murine) Deleted in Azoospermia-Like (DAZL) interaction partners

  1. findings demonstrate that DAZL associates with mRNA of Tet1 (show TET1 Proteins), a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 (show TET1 Proteins) mRNA translation; DAZL enhances TET1 (show TET1 Proteins)-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state

  2. Both yeast and mouse contain an RNA-binding protein, Rim4 (show RIMS4 Proteins) and DAZL, respectively, that functions in translation and forms SDS (show SDS Proteins)-resistant aggregates during gametogenesis.

  3. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 (show REC8 Proteins) induction and function

  4. Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs).

  5. demonstrate that Boll (show BOLL Proteins) is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl

  6. Studies indicate that in Dazl-Knockout mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign.

  7. alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8.

  8. DAZL was translocated to stress granules upon heat stress. Furthermore, stress granule assembly was significantly diminished in the early male germ cells of Dazl-knockout mice. DAZL induced the sequestration of signaling molecules such as RACK (show GNB2L1 Proteins).

  9. structures suggest that the number of DAZL molecules bound to GUU triplets in the 3'-UTR provides a method for modulating the translation of a target RNA

  10. If DAZL expression is reduced, then follicles can grow to the late follicular stage despite declining levels of circulating FSH (show BRD2 Proteins), leading to more follicles ovulating and increased litter size.

Cow (Bovine) Deleted in Azoospermia-Like (DAZL) interaction partners

  1. analysis of genomic structure and transcript variants of the bovine DAZL gene

Xenopus laevis Deleted in Azoospermia-Like (DAZL) interaction partners

  1. The dynamic intracellular localization suggests that Dazl is a multifunctional protein regulating RNA metabolism required for Xenopus germline development

  2. Daz- and pumilio-like genes are asymmetrically localized in Pelophylax (Rana) oocytes and are expressed during early spermatogenesis.

  3. Dazl has the ability to stimulate translation and function at the level of translation initiation.

Zebrafish Deleted in Azoospermia-Like (DAZL) interaction partners

  1. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a (show WNT8A Proteins), grip2a, and Dazl, in the zebrafish embryo have been presented.

  2. that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.

  3. DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish

  4. Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates.

DAZL Protein Profile

Protein Summary

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DAZL

  • deleted in azoospermia-like (dazl)
  • deleted in azoospermia-like (DAZL)
  • deleted in azoospermia-like (LOC100453294)
  • deleted in azoospermia-like (LOC100484743)
  • deleted in azoospermia-like (LOC100542379)
  • deleted in azoospermia-like (LOC100556590)
  • deleted in azoospermia-like (LOC100579498)
  • deleted in azoospermia-like (LOC100625706)
  • deleted in azoospermia-like (Dazl)
  • Daz-like protein
  • Dazh protein
  • DAZL protein
  • dazl-a protein
  • dazl-B protein
  • Dazl1 protein
  • Dazla protein
  • SPGYLA protein
  • Tpx-2 protein
  • Tpx2 protein
  • Xdazl protein

Protein level used designations for DAZL

DAZ-like protein , xtdazl , deleted in azoospermia-like , DAZ homolog , DAZ-like autosomal , SPGY-like-autosomal , deleted in azoospermia-like 1 , germline specific RNA binding protein , spermatogenesis gene on the Y-like autosomal , deleted in azoospermia protein 3 , deleted in azoospermia-like protein , DAZ-like protein A , DAZ-like protein B , Deleted in azoospermia-like-B , deleted in azoospermia-like-A , xDazl-A , xDazl-B , Deleted in azoospermia-like 1

GENE ID SPECIES
394676 Xenopus (Silurana) tropicalis
695763 Macaca mulatta
100453294 Pongo abelii
100484743 Ailuropoda melanoleuca
100542379 Meleagris gallopavo
100556590 Anolis carolinensis
100579498 Nomascus leucogenys
100625706 Sus scrofa
1618 Homo sapiens
13164 Mus musculus
680486 Rattus norvegicus
477055 Canis lupus familiaris
530116 Bos taurus
100579146 Sus scrofa
374054 Gallus gallus
398041 Xenopus laevis
100410648 Callithrix jacchus
58039 Danio rerio
460209 Pan troglodytes
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