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Deleted in Bladder Cancer 1 Proteins (DBC1)

DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers.

list all proteins Gene Name GeneID UniProt
Human DBC1 DBC1 1620 O60477
Rat DBC1 DBC1 140610 Q925T8
Mouse DBC1 DBC1 56710 Q920P3
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More Proteins for Deleted in Bladder Cancer 1 (DBC1) Interaction Partners

Human Deleted in Bladder Cancer 1 (DBC1) interaction partners

  1. we found that the SIRT1 (show SIRT1 Proteins) modulators AROS (show RPS19BP1 Proteins) and DBC1 have an impact on hsp70 (show HSP70 Proteins) transcription, HSF1 (show HSF1 Proteins) acetylation status, and HSF1 (show HSF1 Proteins) recruitment to the hsp70 (show HSP70 Proteins) promoter

  2. DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha (show NR1D1 Proteins).

  3. the stress-induced DBC1-SIRT1 (show SIRT1 Proteins) interaction is important for cell fate determination following genotoxic stress.

  4. Rxpression of DBC1 and SIRT1 (show SIRT1 Proteins) is a significant prognostic indicator for breast carcinoma patients.

  5. High DBC1 expression is associated with breast and lung cancer..

  6. DBCCR1 is involved in the process of bladder tumorigenesis

  7. the prevalent inactivation of DBCCR1 seen at the expression level in astrocytomas is not primarily caused by genomic loss of the gene.

  8. hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies

Mouse (Murine) Deleted in Bladder Cancer 1 (DBC1) interaction partners

  1. DBC1 loss results in less p53 (show TP53 Proteins) protein in vitro and in vivo.

  2. inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-kappaB (show NFKB1 Proteins) pathway upon CD40 (show CD40 Proteins) stimulation

  3. Absence of BRINP1 causes deregulation of neurogenesis and impairments of neuronal differentiation in adult hippocampal circuitry.

  4. Data show that neuron-restrictive silencing factor (NRSF) plays a role in the neural-selective expression of BMP/RA-inducible neural-specific protein 1 (show DPYSL3 Proteins).

  5. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.

  6. The authors show that retinoic acid-inducible gene (RIG)-I (show DDX58 Proteins)-like receptors (RLRs) in cooperation with Toll (show TLR4 Proteins)-like receptor (TLR) 9 (show TLR9 Proteins) is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV).

Deleted in Bladder Cancer 1 (DBC1) Protein Profile

Protein Summary

This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.

Gene names and symbols associated with DBC1

  • deleted in bladder cancer 1 (DBC1)
  • deleted in bladder cancer 1 (LOC100340025)
  • bone morphogenetic protein/retinoic acid inducible neural-specific 1 (BRINP1)
  • bone morphogenetic protein/retinoic acid inducible neural-specific 1 (Brinp1)
  • bone morphogenic protein/retinoic acid inducible neural specific 1 (Brinp1)
  • BRINP protein
  • Dbc1 protein
  • Dbccr1 protein
  • Fam5a protein

Protein level used designations for DBC1

deleted in bladder cancer 1 , deleted in bladder cancer protein 1-like , bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)) , bone morphogenic protein/retinoic acid inducible neural-specific 1 , deleted in bladder cancer chromosome region candidate 1 , deleted in bladder cancer protein 1 , BMP/retinoic acid-inducible neural-specific protein 1 , deleted in bladder cancer protein 1 homolog , BMP/retinoic acid-inducible neural-specific protein (BRINP) , BMP/retinoic acid-inducible neural-specific protein-1

GENE ID SPECIES
100066915 Equus caballus
464694 Pan troglodytes
481694 Canis lupus familiaris
100340025 Oryctolagus cuniculus
100386113 Callithrix jacchus
100457605 Pongo abelii
100602071 Nomascus leucogenys
1620 Homo sapiens
140610 Rattus norvegicus
56710 Mus musculus
395098 Gallus gallus
100625235 Sus scrofa
538990 Bos taurus
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