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anti-Deleted in Liver Cancer 1 (DLC1) Antibodies

DLC1 contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Additionally we are shipping and DLC1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DLC1 10395 Q96QB1
DLC1 50768 Q9R0Z9
DLC1 58834  
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Top anti-DLC1 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DLC1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of DLC-1 on a SK-Hep-1 (human liver adenocarcinoma) lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- human DLC-1 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample(30 μg of whole cell lysate) A:MOLT4, 7.5% SDS PAGE antibody diluted at 1:1500 IHC-P Image Immunohistochemical analysis of paraffin-embedded Pheochromocytoma xenograft, using DLC1, antibody at 1:100 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Goat Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA 100 μg Log in to see 8 to 10 Days
$595.83
Details

DLC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DLC1 Antibodies

  1. Human Monoclonal DLC1 Primary Antibody for IF, WB - ABIN968714 : Homma, Emori: A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. in The EMBO journal 1995 (PubMed)
    Show all 3 references for ABIN968714

  2. Human Polyclonal DLC1 Primary Antibody for EIA, IHC (p) - ABIN452680 : Ko, Yeung, Wong, Chan, Poon, Ng, Yam: Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma. in Liver international : official journal of the International Association for the Study of the Liver 2009 (PubMed)

More Antibodies against DLC1 Interaction Partners

Human Deleted in Liver Cancer 1 (DLC1) interaction partners

  1. DLC-1 (show DYNLL1 Antibodies) acts as a tumor suppressor gene in HCC (show FAM126A Antibodies) by regulating the expression of RhoA (show RHOA Antibodies)/ROCK2 (show ROCK2 Antibodies)/ moesin (show MSN Antibodies).

  2. Low DLC-1 (show DYNLL1 Antibodies) expression is associated with cancer.

  3. Low expression of DLC1 (show DYNLL1 Antibodies) is predictive of poor therapeutic efficiency of fluoropyrimidine and oxaliplatin as adjuvant chemotherapy in gastric cancer.

  4. No significant association of DLC1 (show DYNLL1 Antibodies) SNPs with the patients' prognosis was found.

  5. A phosphorylation-mediated molecular switch comprising DLC), TNS3 (show TNS3 Antibodies), PTEN (show PTEN Antibodies) and PI3K (show PIK3CA Antibodies) controls the spatiotemporal activation of Rac1 and RhoA (show RHOA Antibodies), thereby initiating directional cell migration induced by growth factors.

  6. Data suggest BCL2-like 1 (show BCL2L1 Antibodies) protein (BCL2L1 (show BCL2L1 Antibodies)) and deleted in liver cancer 1 protein (DLC1) as potential druggable targets for specific subsets of gastric cancer (GC) cases.

  7. DLEC1 (show DLEC1 Antibodies) mediates tumor-suppressive activities through NF-kappaB (show NFKB1 Antibodies) signaling.

  8. Low DLC1 (show DYNLL1 Antibodies) expression is associated with cancer.

  9. During early cell spreading, DLC1 (show DYNLL1 Antibodies) is preferentially localized at the inner/mature adhesions whereas phosphorylated paxillin (show PXN Antibodies) occupies the outer/nascent focal adhesions. In addition, DLC1 (show DYNLL1 Antibodies) downregulates paxillin (show PXN Antibodies) turnover

  10. Cooperation of DLC1 (show DYNLL1 Antibodies) and CDK6 (show CDK6 Antibodies) affects breast cancer clinical outcome

Mouse (Murine) Deleted in Liver Cancer 1 (DLC1) interaction partners

  1. studies demonstrate that TNS1 (show TNS1 Antibodies) binds to DLC1 and fine-tunes its RhoGAP (show ARHGAP1 Antibodies) activity toward RhoA (show RHOA Antibodies) and that the TNS1 (show TNS1 Antibodies)-DLC1-RhoA (show RHOA Antibodies) signaling axis is critical in regulating cellular functions that lead to angiogenesis

  2. Loss of expression of only Dlc1 isoform 2 may be sufficient for the development of thymic tumors and metastasis.

  3. Several genes and biochemical activities collaborate with the inactivation of DLC1 to give rise to cell transformation in MEFs, and the identified genes are relevant to human tumors with low DLC1 expression.

  4. The Dlc1 deficient cells showed altered cytoskeleton structure, increased RhoA (show RHOA Antibodies) activity and cellular migration.

  5. DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta

  6. Our data validate DLC1 as a potent tumor suppressor gene and suggest that its loss creates a dependence on the RhoA (show RHOA Antibodies) pathway that may be targeted therapeutically.

DLC1 Antigen Profile

Protein Summary

This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney.

Gene names and symbols associated with DLC1

  • deleted in liver cancer 1 (dlc1) antibody
  • deleted in liver cancer 1 (DLC1) antibody
  • deleted in liver cancer 1 (Dlc1) antibody
  • deleted in lung and esophageal cancer 1 (DLEC1) antibody
  • A730069N07Rik antibody
  • Arhgap7 antibody
  • Dlc-1 antibody
  • DLC1 antibody
  • F56 antibody
  • HP antibody
  • p122-RhoGAP antibody
  • RhoGAP antibody
  • rhogap7 antibody
  • StARD12 antibody

Protein level used designations for DLC1

deleted in liver cancer 1 , rho GTPase-activating protein 7-like , Rho-GTPase-activating protein 7 , START domain-containing protein 12 , StAR-related lipid transfer (START) domain containing 12 , deleted in liver cancer 1 protein , deleted in liver cancer 1 variant 2 , rho GTPase-activating protein 7 , rho-type GTPase-activating protein 7 , p122-RhoGAP , stAR-related lipid transfer protein 12 , deleted in liver cancer 1 protein homolog , dlc-1 , rho GTPase activating protein 7 , stARD12 , Deleted in liver cancer 1 protein homolog , Rho-type GTPase-activating protein 7 , DLC-1 , deleted in lung and esophageal cancer 1 transcript varient 2 , deleted in lung and esophageal cancer protein 1

GENE ID SPECIES
431800 Xenopus laevis
422740 Gallus gallus
464001 Pan troglodytes
700630 Macaca mulatta
100022416 Monodelphis domestica
100052317 Equus caballus
100352546 Oryctolagus cuniculus
100470350 Ailuropoda melanoleuca
100488460 Xenopus (Silurana) tropicalis
100456847 Pongo abelii
100553915 Anolis carolinensis
100598737 Nomascus leucogenys
10395 Homo sapiens
50768 Mus musculus
58834 Rattus norvegicus
511433 Bos taurus
475607 Canis lupus familiaris
9940 Homo sapiens
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