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anti-Delta(4)-Desaturase, Sphingolipid 1 (DEGS1) Antibodies

DEGS1 encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. Additionally we are shipping Delta(4)-Desaturase, Sphingolipid 1 Kits (5) and Delta(4)-Desaturase, Sphingolipid 1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DEGS1 13244 O09005
DEGS1 8560 O15121
DEGS1 58970 Q5XIF5
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Top anti-Delta(4)-Desaturase, Sphingolipid 1 Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemical staining of normal human brain tissue using DEGS1 Antibody at 15 µg/ml. 10 blots Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated IHC (p), WB DEGS1 Antibody (N-term) (ABIN657334) western blot analysis in T47D cell line lysates (35 µg/lane). This demonstrates the DEGS1 antibody detected the DEGS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged DEGS1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), WB Human, Lung: Formalin-Fixed Paraffin-Embedded (FFPE) Human, Skin: Formalin-Fixed Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC, WB 10 blots Log in to see 8 to 10 Days
$654.50
Details
Human Mouse Un-conjugated ELISA, WB DEGS1 monoclonal antibody (M01A), clone 3F9. Western Blot analysis of DEGS1 expression in HepG2 . 200 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

DEGS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Delta(4)-Desaturase, Sphingolipid 1 Antibodies

  1. Human Polyclonal DEGS1 Primary Antibody for IHC (p), WB - ABIN265289 : Cadena, Kurten, Gill: The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis. in Biochemistry 1997 (PubMed)
    Show all 2 references for ABIN265289

  2. Human Polyclonal DEGS1 Primary Antibody for WB - ABIN265290 : Ternes, Franke, Zähringer, Sperling, Heinz: Identification and characterization of a sphingolipid delta 4-desaturase family. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN265290

  3. Human Polyclonal DEGS1 Primary Antibody for IHC (p), WB - ABIN657334 : Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. in Genomics 2007 (PubMed)

  4. Chicken Polyclonal DEGS1 Primary Antibody for WB - ABIN2782243 : Kraveka, Li, Szulc, Bielawski, Ogretmen, Hannun, Obeid, Bielawska: Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against Delta(4)-Desaturase, Sphingolipid 1 Interaction Partners

Mouse (Murine) Delta(4)-Desaturase, Sphingolipid 1 (DEGS1) interaction partners

  1. genetic ablation of DEGS1 in preadipocytes prevented adipogenesis and decreased lipid accumulation. This was associated with elevated oxidative stress, cellular death, and blockage of the cell cycle.

  2. The role of Degs1 in the hypoxic mouse heart.Hand2 and NFATC physically interact on the DEGS1 promoter.

  3. Ablation of dihydroceramide desaturase 1 simultaneously stimulates anabolic and catabolic signaling.

  4. Des1 ablation activated pro-survival and anabolic signaling intermediates (e.g. Akt/PKB (show AKT1 Antibodies), mTOR (show FRAP1 Antibodies), MAPK (show MAPK1 Antibodies), etc.) and provided protection from apoptosis caused by etoposide.

  5. overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia

  6. analysis of dihydroceramide desaturase regulation by palmitate versus monounsaturated fatty acids and its implications for insulin (show INS Antibodies) resistance

  7. Data show that CS-mediated SCC (show CYP11A1 Antibodies) lethality was mitigated in irradiated gain-of-function Rad50 (show RAD50 Antibodies)(s/s) mice, and epistasis studies order Rad50 (show RAD50 Antibodies) upstream of Mre11 (show MRE11A Antibodies).

  8. GT11 is the first specific inhibitor of dihydroceramide desaturase described so far

Human Delta(4)-Desaturase, Sphingolipid 1 (DEGS1) interaction partners

  1. ABC294640 may reduce the proliferative capacity of castration-resistant prostate cancer cells through inhibition of both sphingosine kinase 2 (show SPHK2 Antibodies) and dihydroceramide desaturase.

  2. Dihydroceramide desaturase 1 (DES (show DES Antibodies)) is a potential molecular target for regulating apoptotic resistance to photodynamic therapy

  3. changes in lipid homeostasis and gene expression in Huh7 hepatocytes when the synthesis of ceramide is perturbed by knocking down serine pal mitoyltransferase subunits 1, 2, and 3 (SPTLC123) or dihydroceramide desaturase 1 (DEGS1)

  4. a role of the sphingolipid pathway, dihydroceramides desaturase in particular, in confluence-induced growth arrest in neuroblastoma (show ARHGEF16 Antibodies) cells

  5. overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia

  6. oxidative stress leads to potent inhibition of dihydroceramide desaturase resulting in significant elevation in dihydroceramide levels in vivo

  7. identification of sphingolipid delta 4-desaturase family

  8. partial loss of DEGS-1 inhibited cell growth, with cell cycle arrest at G(0)/G(1). This was accompanied by a significant decrease in the amount of phosphorylated retinoblastoma protein

Delta(4)-Desaturase, Sphingolipid 1 (DEGS1) Antigen Profile

Protein Summary

This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.

Gene names and symbols associated with DEGS1

  • delta(4)-desaturase, sphingolipid 1 (DEGS1) antibody
  • degenerative spermatocyte homolog 1 (Drosophila) (Degs1) antibody
  • degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (degs1) antibody
  • degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (DEGS1) antibody
  • delta(4)-desaturase, sphingolipid 1 (Degs1) antibody
  • AA536663 antibody
  • DEGS antibody
  • DEGS-1 antibody
  • Des-1 antibody
  • DES1 antibody
  • FADS7 antibody
  • im:6909319 antibody
  • Mdes antibody
  • MLD antibody
  • wu:fa25h01 antibody
  • wu:fb81d06 antibody

Protein level used designations for DEGS1

degenerative spermatocyte homolog 1, lipid desaturase , sphingolipid delta(4)-desaturase DES1 , dihydroceramide desaturase , degenerative spermatocyte homolog, lipid desaturase , fb81d06 , cell migration-inducing gene 15 protein , membrane fatty acid (lipid) desaturase , membrane lipid desaturase , migration-inducing gene 15 protein , sphingolipid delta 4 desaturase , sphingolipid delta(4)-desaturase 1 , degenerative spermatocyte-like protein RDES

GENE ID SPECIES
100192315 Ovis aries
13244 Mus musculus
327075 Danio rerio
421327 Gallus gallus
507290 Bos taurus
8560 Homo sapiens
58970 Rattus norvegicus
100135677 Sus scrofa
100171788 Pongo abelii
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