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Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) Proteins (DTL)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. Additionally we are shipping DTL Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DTL 51514 Q9NZJ0
Rat DTL DTL 305073  
DTL 76843 Q3TLR7
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Top DTL Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

DTL Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Interaction Partners

Human Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. CDT2 mediated XPG (show ERCC5 Proteins) elimination from DNA damage sites clears the chromatin space needed for repair.

  2. CDT2 likely is a non-oncogene (show RAB1A Proteins) to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.

  3. These findings reveal C/EBPalpha (show CEBPA Proteins) regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21 (show CDKN1A Proteins).

  4. CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.

  5. while interaction with PCNA (show PCNA Proteins) was important for targeting p21 (show CDKN1A Proteins) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  6. CRL4(Cdt2)-dependent degradation of TDG (show TDG Proteins) occurs in S phase because of the requirement for TDG (show TDG Proteins) to interact with chromatin-loaded PCNA (show PCNA Proteins), and this degradation is important for preventing toxicity from excess TDG (show TDG Proteins).

  7. Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.

  8. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

  9. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.

  10. Data indicate that depleting ubiquitin E3 ligase CRL4(CDT2/DCAF2) mimicked the pharmacological effects of MLN4924.

Mouse (Murine) Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. while interaction with PCNA (show PCNA Proteins) was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  2. L2dtl gene expression is essential for very early mouse embryonic development

DTL Protein Profile

Protein Summary

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (DTL)
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (Dtl)
  • denticleless homolog (Drosophila) (Dtl)
  • 2810047L02Rik protein
  • 5730564G15Rik protein
  • CDT2 protein
  • DCAF2 protein
  • L2DTL protein
  • Ramp protein
  • RGD1310439 protein

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein

GENE ID SPECIES
51514 Homo sapiens
490279 Canis lupus familiaris
539953 Bos taurus
305073 Rattus norvegicus
421373 Gallus gallus
76843 Mus musculus
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