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anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Antibodies

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. Additionally we are shipping DTL Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DTL 51514 Q9NZJ0
DTL 305073  
DTL 76843 Q3TLR7
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Top anti-DTL Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DTL Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, WB DTL Antibody (Center) (ABIN654926) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of Hela cells using CDT2 / DTL Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of CDT2 / DTL Antibody  in mouse spleen tissue lysates (35ug/lane). This demonstrates the DTL antibody detected the DTL protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: DTL/CDT2 Antibody [ABIN251524] - Detection of Human DTL/CDT2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- DTL/CDT2 antibody ABIN251524 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DTL/CDT2 was also immunoprecipitated by other rabbit anti- DTL/CDT2 antibodies and ABIN251523, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). Immunohistochemistry-Paraffin: CDT2 Antibody [ABIN2515240] - Human colon carcinoma (left) and mouse hybridoma tumor (right). Antibody used at a dilution of 1:1,000. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunofluorescence: CDT2 Antibody [NBP1-85283] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: CDT2 Antibody [NBP1-85283] - Staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated FACS, IF, IP, WB 100 μL Log in to see 7 to 8 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western Blot: CDT2 Antibody [NBP1-54644] - 721_B cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 7 to 9 Days
$383.17
Details
Human Rabbit Un-conjugated WB DTL antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

DTL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Rat (Rattus)


Mouse (Murine) ,


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Top referenced anti-DTL Antibodies

  1. Human Polyclonal DTL Primary Antibody for ICC, IF - ABIN251524 : Jørgensen, Eskildsen, Fugger, Hansen, Larsen, Kousholt, Syljuåsen, Trelle, Jensen, Helin, Sørensen: SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. in The Journal of cell biology 2011 (PubMed)
    Show all 4 references for ABIN251524

  2. Human Polyclonal DTL Primary Antibody for EIA, FACS - ABIN951451 : Centore, Havens, Manning, Li, Flynn, Tse, Jin, Dyson, Walter, Zou: CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. in Molecular cell 2010 (PubMed)
    Show all 3 references for ABIN951451

  3. Human Polyclonal DTL Primary Antibody for FACS, WB - ABIN654926 : Abbas, Shibata, Park, Jha, Karnani, Dutta: CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. in Molecular cell 2010 (PubMed)
    Show all 3 references for ABIN654926

  4. Cow (Bovine) Polyclonal DTL Primary Antibody for WB - ABIN2782560 : Sansam, Shepard, Lai, Ianari, Danielian, Amsterdam, Hopkins, Lees: DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. in Genes & development 2006 (PubMed)

  5. Human Polyclonal DTL Primary Antibody for ICC, IF - ABIN4297129 : Karaayvaz, Pal, Song, Zhang, Georgakopoulos, Mehmood, Burke, Shroyer, Ju: Prognostic significance of miR-215 in colon cancer. in Clinical colorectal cancer 2011 (PubMed)

More Antibodies against DTL Interaction Partners

Human Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. Findings suggest that DTL (show TNFSF13B Antibodies) overexpression plays a crucial role in tumor cell proliferation in gastric carcinoma.

  2. CDT2 mediated XPG (show ERCC5 Antibodies) elimination from DNA damage sites clears the chromatin space needed for repair.

  3. CDT2 likely is a non-oncogene (show RAB1A Antibodies) to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.

  4. These findings reveal C/EBPalpha (show CEBPA Antibodies) regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21 (show CDKN1A Antibodies).

  5. CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.

  6. while interaction with PCNA (show PCNA Antibodies) was important for targeting p21 (show CDKN1A Antibodies) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  7. CRL4(Cdt2)-dependent degradation of TDG (show TDG Antibodies) occurs in S phase because of the requirement for TDG (show TDG Antibodies) to interact with chromatin-loaded PCNA (show PCNA Antibodies), and this degradation is important for preventing toxicity from excess TDG (show TDG Antibodies).

  8. Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.

  9. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

  10. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.

Mouse (Murine) Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) interaction partners

  1. while interaction with PCNA (show PCNA Antibodies) was important for targeting p21 (show D4S234E Antibodies) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  2. L2dtl gene expression is essential for very early mouse embryonic development

DTL Antigen Profile

Protein Summary

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (DTL) antibody
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (Dtl) antibody
  • denticleless homolog (Drosophila) (Dtl) antibody
  • 2810047L02Rik antibody
  • 5730564G15Rik antibody
  • CDT2 antibody
  • DCAF2 antibody
  • L2DTL antibody
  • Ramp antibody
  • RGD1310439 antibody

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein

GENE ID SPECIES
51514 Homo sapiens
490279 Canis lupus familiaris
539953 Bos taurus
305073 Rattus norvegicus
421373 Gallus gallus
76843 Mus musculus
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