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Dentin Sialophosphoprotein Proteins (DSPP)

DSPP encodes two principal proteins of the dentin extracellular matrix of the tooth. Additionally we are shipping Dentin Sialophosphoprotein Kits (36) and Dentin Sialophosphoprotein Antibodies (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DSPP 666279  
DSPP 25254  
DSPP 1834 Q9NZW4
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Top Dentin Sialophosphoprotein Proteins at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,947.17
Details

DSPP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human

More Proteins for Dentin Sialophosphoprotein (DSPP) Interaction Partners

Mouse (Murine) Dentin Sialophosphoprotein (DSPP) interaction partners

  1. Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 (show DMP1 Proteins) and Dspp transcription.

  2. DMOG can enhance Dspp expression through VEGF (show VEGFA Proteins)-induced stabilization of Runx2 (show RUNX2 Proteins) protein.

  3. total dentin volume in DSPP KO animals significant changes in the ultrastructural organization exist

  4. the expression of DSPP precursor protein is required for normal odontoblast lineage differentiation

  5. DPP is essential for the formation of well-defined tooth structures with mineralized dentin matrix.

  6. continuous DSPP action is required for the growth and/or maintenance of the mandibular condylar cartilage

  7. Data indicate that that Wnt10a (show WNT10A Proteins) regulates Dspp expression in mesenchymal cells.

  8. Inactivation of DSPP leads to loss of alveolar bone and cementum in PDL of Dspp null mice. loss of DSPP results in periodontal diseases indicates that this molecule plays vital role in maintaining health of periodontium.

  9. DSS (show PMP22 Proteins) domain of DPP functions as a novel cell-penetrating peptide, and these findings demonstrate new opportunities for intracellular delivery of therapeutic proteins and cell tracking in vivo.

  10. Results indicate that dentin sialophosphoprotein (DSPP) is a downstream effector molecule that mediates the roles of dentin matrix protein 1 (DMP1 (show DMP1 Proteins)) in dentinogenesis.

Human Dentin Sialophosphoprotein (DSPP) interaction partners

  1. A novel pathogenic splicing-mutation c.52-1G>A of DSPP is associated with dentinogenesis imperfecta shields type II.

  2. expression of MMP-20 (show MMP20 Proteins) and co-expression and potential interaction with DSPP in human major salivary gland tissues

  3. mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency

  4. DMP1 (show DMP1 Proteins) and DSPP were more abundant in carious than in sound samples.

  5. Domain of dentine sialoprotein mediates proliferation and differentiation of human periodontal ligament stem cells.

  6. analysis of a mutation in DSPP causing dentinogenesis imperfecta and characterization of the mutational effect

  7. DSS (show NR0B1 Proteins) domain of DPP functions as a novel cell-penetrating peptide, and these findings demonstrate new opportunities for intracellular delivery of therapeutic proteins and cell tracking in vivo.

  8. efficiency of dentin sialoprotein-phosphophoryn processing is affected by mutations both flanking and distant from the cleavage site

  9. A review of hereditary dentine diseases resulting from mutations in DSPP gene suggests that the localization of mutation in the sequence of the DSPP gene might result in a different phenotype due to the diverse cellular fate of the mutated protein.

  10. Data shows all known DSPP mutations (except Y6D) cause nonsyndromic dentin dysplasia,DD-II, and dentinogenesis imperfecta, DGI (show DSG1 Proteins) II & III, by retention of mutant proteins in the endoplasmic reticulum with associated decreased secretion of normal DSPP.

Pig (Porcine) Dentin Sialophosphoprotein (DSPP) interaction partners

  1. The porcine dentin sialophosphoprotein has an N-terminal domain with at least six N-glycosylations and a C-terminal domain with two glycosaminoglycan attachments and at least two O-glycosylations.

  2. Astacins in the predentin matrix cleave Dspp.

  3. isolation of DSP from pig dentin and demonstration that it is a proteoglycan (show Vcan Proteins)

  4. isolation and characterization of a third domain of DSPP, designated dentin glycoprotein (DGP)

  5. correspondence between DSPP cleavage sites that occur in vivo and those generated in vitro demonstrates that MMP-2 (show MMP2 Proteins) and MMP-20 (show MMP20 Proteins) process DSPP into smaller subunits in the dentin matrix during odontogenesis

  6. DPP length variations are polymorphic and are not associated with dentin defects

  7. porcine DPP-derived arginyl-glycyl-aspartic acid peptide, but not its mutant arginyl-alanyl-aspartic acid peptide, significantly promoted cell migration

Dentin Sialophosphoprotein (DSPP) Protein Profile

Protein Summary

This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1\; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.

Gene names and symbols associated with DSPP

  • dentin sialophosphoprotein (DSPP)
  • dentin sialophosphoprotein (Dspp)
  • dentin sialophosphoprotein (Patl_2314)
  • DFNA39 protein
  • DGI1 protein
  • Dmp2 protein
  • DMP3 protein
  • DPP protein
  • DSP protein
  • DTDP2 protein
  • RDSP2 protein

Protein level used designations for DSPP

dentin sialophosphoprotein , DMP-3 , dentin matrix protein 3 , Dentin sialoprotein , Dentine sialoprotein , dentin sailophosphoprotein , dentin phosphophoryn , dentin phosphoprotein , dentin phosphoryn , dentin sialoprotein

GENE ID SPECIES
487849 Canis lupus familiaris
551799 Apis mellifera
100080849 Ornithorhynchus anatinus
4172468 Pseudoalteromonas atlantica T6c
666279 Mus musculus
25254 Rattus norvegicus
1834 Homo sapiens
101789124 Cavia porcellus
396664 Sus scrofa
100683557 Canis lupus familiaris
100337125 Bos taurus
776475 Gallus gallus
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