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Deoxycytidine Kinase Proteins (DCK)

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Additionally we are shipping DCK Antibodies (106) and DCK Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCK 1633 P27707
DCK 13178 P43346
DCK 79127 P48769
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Top DCK Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,673.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,673.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$4,009.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$534.64
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details

DCK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced DCK Proteins

  1. Human DCK Protein expressed in Escherichia coli (E. coli) - ABIN667827 : Toy, Austin, Liao, Cheng, Singh, Campbell, Ishikawa, Lehmann, Satyamurthy, Phelps, Herschman, Czernin, Witte, Radu: Requirement for deoxycytidine kinase in T and B lymphocyte development. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for ABIN667827

More Proteins for Deoxycytidine Kinase (DCK) Interaction Partners

Human Deoxycytidine Kinase (DCK) interaction partners

  1. recently described a human deoxycytidine kinase mutant (G12 (show TCF3 Proteins)) that sensitizes cancer cell lines to treatment with gemcitabine. Here, starting from the G12 (show TCF3 Proteins) variant, we identified a mutant that triggers even greater sensitisation to gemcitabine than G12 (show TCF3 Proteins).

  2. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1 (show SLC29A1 Proteins)) and ribonucleotide reductase M1 (RRM1 (show RRM1 Proteins)) were significantly higher and cytidine deaminase (CDA (show CDA Proteins)) was significantly lower in ex vivo Ara (show FOXC1 Proteins)-C sensitive samples.

  3. n the multivariate Cox (show COX8A Proteins) regression analysis, we found that age at diagnosis, wild-type genotype of the CDA (show CDA Proteins) A79C polymorphism, and wild-type genotype of the dCK C360G polymorphism were the most significant prognostic factors for predicting the risk of death

  4. results strongly suggest that (1) the E197K alteration in DCK causes inactivation of DCK, and that (2) loss of the normal E197 allele is the crucial mechanism in acquisition of gemcitabine resistance in the RMKN28 tumor cell line

  5. DCK rs12648166 and DCK rs4694362 SNPs were associated with hematologic toxicity (OR = 2.63, CI 95% = 1.37-5.04, P = 0.0036 and OR = 2.53, CI 95% = 1.34-4.80, P = 0.0044, respectively).

  6. These findings indicate that the decitabine metabolic pathway affects its therapeutic effects, lower hENT1 expression may induce primary resistance and down-regulated DCK expression may be related to secondary resistance.

  7. DCK expression levels are prognostic and had predictive value for sensitivity to 5-FU in pancreatic cancer.

  8. DCK could regulate the migration and invasion of fibroblast-like synoviocytes through AKT (show AKT1 Proteins) pathway in rheumatoid arthritis patients.

  9. PP2A (show PPP2R4 Proteins) constitutively dephosphorylates dCK in cells and negatively regulates its activity.

  10. Report genetic variation in deoxycytidine kinase and subsequent gemcitabine metabolism.

Mouse (Murine) Deoxycytidine Kinase (DCK) interaction partners

  1. Mutation of a single serine 74 residue has profound effects on murine T and B lymphocyte (show AKAP17A Proteins) development, suggesting that post-translational regulation of dCK has a role in maintaining genomic stability during hematopoiesis.

  2. activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement and suggests a novel therapeutic target for the treatment of COPD (show ARCN1 Proteins)

  3. Deoxycytidine kinase is a new regulator of hematopoietic integrity and lymphocyte quiescence and survival.

  4. The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the de novo pathway.

DCK Protein Profile

Protein Summary

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.

Gene names and symbols associated with Deoxycytidine Kinase Proteins (DCK)

  • Deoxycytidine kinase (dck)
  • deoxycytidine kinase, gene 2 (dck.2)
  • deoxycytidine kinase (DCK)
  • zgc:110540 (zgc:110540)
  • Deoxycytidine kinase (FPV059)
  • Deoxycytidine kinase (FPV151)
  • deoxycytidine kinase (Dck)
  • deoxycytidine kinase (dck)
  • deoxycytidine kinase, gene 1 (dck.1)
  • Dck protein
  • dck1 protein
  • dck2 protein
  • wu:fc15f06 protein
  • wu:fe11h12 protein
  • wu:fj05e11 protein
  • zgc:101771 protein
  • zgc:109951 protein

Protein level used designations for Deoxycytidine Kinase Proteins (DCK)

Deoxycytidine kinase , deoxycytidine kinase , deoxynucleoside kinase , deoxycytidine kinase 1 , deoxyribonucleoside kinase

GENE ID SPECIES
100196160 Salmo salar
446773 Xenopus laevis
549546 Xenopus (Silurana) tropicalis
100305233 Oncorhynchus mykiss
461273 Pan troglodytes
705040 Macaca mulatta
541538 Danio rerio
1486607 Fowlpox virus
1486699 Fowlpox virus
1633 Homo sapiens
13178 Mus musculus
474325 Danio rerio
422648 Gallus gallus
482188 Canis lupus familiaris
530642 Bos taurus
79127 Rattus norvegicus
496391 Xenopus laevis
Selected quality suppliers for DCK Proteins (DCK)
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