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Deoxyhypusine Hydroxylase/monooxygenase Proteins (DOHH)

DOHH encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. Additionally we are shipping Deoxyhypusine Hydroxylase/monooxygenase Antibodies (6) and Deoxyhypusine Hydroxylase/monooxygenase Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DOHH 83475 Q9BU89
DOHH 102115 Q99LN9
Rat DOHH DOHH 314644 Q5PPJ4
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Top Deoxyhypusine Hydroxylase/monooxygenase Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,794.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,806.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,812.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DOHH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Deoxyhypusine Hydroxylase/monooxygenase (DOHH) Interaction Partners

Human Deoxyhypusine Hydroxylase/monooxygenase (DOHH) interaction partners

  1. Data describes 3-D structure of hDOHH in two states, hDOHHperoxo (POX (show PRODH Proteins)) and a complex of the diiron core with glycerol (GLC) providing an explanation for the extreme longevity of POX (show PRODH Proteins) and illustrate its substrate specificity for deoxyhypusine-eIF-5A (show EIF5 Proteins).

  2. Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.

  3. eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample

  4. a novel role for miR (show MLXIP Proteins)-331-3p and miR (show MLXIP Proteins)-642-5p in the control of prostate cancer cell growth via the regulation of DOHH expression and eIF5A (show EIF5 Proteins) activity.

  5. The structure and function of DOHH are reported.

  6. analysis of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (show EIF2A Proteins) (eIF5A (show EIF5 Proteins)) interaction

  7. Resonance Raman experiments show that its blue chromophore arises from a (mu-1,2-peroxo)diiron(III) center that forms in the reaction of the reduced enzyme with O2, so the peroxo form of hDOHH is unusually stable.

Mouse (Murine) Deoxyhypusine Hydroxylase/monooxygenase (DOHH) interaction partners

  1. Deletion of hypusine modification enzymes ( deoxyhypusine synthase (show DHPS Proteins) and deoxyhypusine hydroxylase )exerts strong phenotypes. eIF-5A2 (show EIF5A2 Proteins)-deleted animals are viable and fertile.

  2. An evolutionarily conserved role for the DOHH-mediated second step of hypusine synthesis in early embryonic development, is reported.

Cow (Bovine) Deoxyhypusine Hydroxylase/monooxygenase (DOHH) interaction partners

  1. We describe the cloning and characterization of bovine deoxyhypusine hydroxylase cDNA.

Deoxyhypusine Hydroxylase/monooxygenase (DOHH) Protein Profile

Protein Summary

This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with DOHH

  • deoxyhypusine hydroxylase/monooxygenase (DOHH)
  • deoxyhypusine hydroxylase/monooxygenase (Dohh)
  • deoxyhypusine hydroxylase/monooxygenase (dohh)
  • 1110033C18Rik protein
  • AI585913 protein
  • AL022869 protein
  • fb33c04 protein
  • hDOHH protein
  • hlrc1 protein
  • RGD1304783 protein
  • wu:fb33c04 protein
  • zgc:56338 protein

Protein level used designations for DOHH

deoxyhypusine hydroxylase/monooxygenase , HEAT-like (PBS lyase) repeat containing 1 , deoxyhypusine hydroxylase , deoxyhypusine hydroxylase-like , lethal s1921 , HEAT-like repeat-containing protein 1 , deoxyhypusine dioxygenase , deoxyhypusine monooxygenase

GENE ID SPECIES
455584 Pan troglodytes
485060 Canis lupus familiaris
713046 Macaca mulatta
100135444 Ovis aries
100188970 Bombyx mori
83475 Homo sapiens
102115 Mus musculus
314644 Rattus norvegicus
526521 Bos taurus
427066 Gallus gallus
321732 Danio rerio
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