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DOHH encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. Additionally we are shipping Deoxyhypusine Hydroxylase/monooxygenase Antibodies (7) and Deoxyhypusine Hydroxylase/monooxygenase Kits (5) and many more products for this protein.
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Data describes 3-D structure of hDOHH in two states, hDOHHperoxo (POX (show PRODH Proteins)) and a complex of the diiron core with glycerol (GLC) providing an explanation for the extreme longevity of POX (show PRODH Proteins) and illustrate its substrate specificity for deoxyhypusine-eIF-5A (show EIF5 Proteins).
Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A.
eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample
a novel role for miR (show MLXIP Proteins)-331-3p and miR (show MLXIP Proteins)-642-5p in the control of prostate cancer cell growth via the regulation of DOHH expression and eIF5A (show EIF5 Proteins) activity.
The structure and function of DOHH are reported.
analysis of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (show EIF2A Proteins) (eIF5A (show EIF5 Proteins)) interaction
Resonance Raman experiments show that its blue chromophore arises from a (mu-1,2-peroxo)diiron(III) center that forms in the reaction of the reduced enzyme with O2, so the peroxo form of hDOHH is unusually stable.
Deletion of hypusine modification enzymes ( deoxyhypusine synthase (show DHPS Proteins) and deoxyhypusine hydroxylase )exerts strong phenotypes. eIF-5A2 (show EIF5A2 Proteins)-deleted animals are viable and fertile.
An evolutionarily conserved role for the DOHH-mediated second step of hypusine synthesis in early embryonic development, is reported.
We describe the cloning and characterization of bovine deoxyhypusine hydroxylase cDNA.
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.
, HEAT-like (PBS lyase) repeat containing 1
, deoxyhypusine hydroxylase
, deoxyhypusine hydroxylase-like
, lethal s1921
, HEAT-like repeat-containing protein 1
, deoxyhypusine dioxygenase
, deoxyhypusine monooxygenase