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DNASE1 encodes a member of the DNase family. Additionally we are shipping Deoxyribonuclease I Antibodies (81) and Deoxyribonuclease I Kits (65) and many more products for this protein.
Showing 10 out of 24 products:
Specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes.
TNF-alpha (show TNF Proteins) amplifies DNaseI expression in renal tubular cells while IL-1beta (show IL1B Proteins) promotes nuclear DNaseI translocation in inactive form in lupus nephritis.
HumDN1 polymorphisms were examined in blood of 11 worldwide populations by polymerase chain reaction. 15 genotypes were found leading to the conclusion that HumDN1 variable no. tandem repeats are ethnic group specific.
Val66Met in the BDNF (show BDNF Proteins) gene and two SNPs, Fokl and Apal, in the VDR (show CYP27B1 Proteins) gene may potentially be associated with DED (show AATF Proteins). Additionally, the association between DED (show AATF Proteins) and Val66Met may vary by depression status.
In conclusion, elevated DNase I in diabetes may be related to pancreatic injury and could be one of the causes that induce diabetes.
Our results indicate that increased DNASE1 expression is common to both SLE and RA, while DNase1 reduction activity is specific to SLE.
Characterization of the nonsynonymous single-nucleotide polymorphism variants of human DNASE1.
DNase I activity in systemic lupus erythematosus patients was lower than in healthy controls
DNAse I Q222R polymorphism is a potential genetic risk factor for systemic lupus erythematosus in South Indian Tamils. In addition, the mutant allele confers a significant risk for lupus nephritis.
Single nucleotide polymorphisms in the DNASE1 is associated with autoimmune diseases.
a downregulation of the DNASE1 mRNA expression in patients with autoimmune thyroid disease. This might result in degrading less DNA from dying cells, thereby promoting the development of thyroid autoimmunity.
HMGN1 (show HMGN1 Proteins) binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 (show TRAP1 Proteins) and a consequent down-regulation of renal DNaseI by transcriptional interference.
silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll (show TLR4 Proteins) like receptors and Clec4e (show CLEC4E Proteins), leading to progression of both murine and human lupus nephritis
Data show that deletion of DNaseI hypersensitive sites does not have an obvious impact on the IgH locus or B cell development.
Reduction in renal Dnase1 expression and activity is limited to mice and SLE patients with signs of membranoproliferative nephritis, and may be a critical event in the development of severe forms of lupus nephritis.
A conserved sequence located 211 kilobases upstream of class II major histocompatibility complex transcriptional coactivator (CIITA (show CIITA Proteins)) promoter III is hypersensitive to DNase I.
The impact of antibodies to dsDNA, renal Dnase1 and matrix metalloprotease (show ADAMTS7 Proteins) (MMP) mRNA levels and enzyme activities on early and late events in murine lupus nephritis, was determined.
serum Dnase1 in cooperation with the plasminogen (show PLG Proteins) system guarantees a fast and effective breakdown of chromatin during necrosis by the combined cleavage of DNA as well as of DNA binding proteins.
DNase I is essential for kidney injury induced by cisplatin
Results describe chromatin disposal during necrosis and the involvement of Deoxyribonuclease 1 in this process with respect to its possible role in the prevention of anti-nuclear auto-immunity.
Purification and characterization of equine DNase 1 was done; it was confirmed to be of the parotid-type.
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
, DNase I
, Deoxyribonuclease I
, DNase I, lysosomal
, Dornase alfa
, human urine deoxyribonuclease I