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Deoxyuridine Triphosphatase Proteins (DUT)

DUT encodes an essential enzyme of nucleotide metabolism. Additionally we are shipping Deoxyuridine Triphosphatase Antibodies (113) and Deoxyuridine Triphosphatase Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human DUT DUT 1854 P33316
Mouse DUT DUT 110074  
Rat DUT DUT 497778 P70583
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Top Deoxyuridine Triphosphatase Proteins at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Epstein-Barr virus His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Acaryochloris marina His tag   1 mg Log in to see 56 to 66 Days
$2,308.17
Details
Yeast Bacteroides vulgatus His tag   1 mg Log in to see 56 to 66 Days
$2,311.83
Details
Yeast Alkaliphilus metalliredigens His tag   1 mg Log in to see 56 to 66 Days
$2,311.83
Details
Yeast Clostridium His tag   1 mg Log in to see 56 to 66 Days
$2,315.50
Details
Yeast Zymomonas mobilis His tag   1 mg Log in to see 56 to 66 Days
$2,317.33
Details
Yeast Anaplasma marginale His tag   1 mg Log in to see 56 to 66 Days
$2,321.00
Details

DUT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced Deoxyuridine Triphosphatase Proteins

  1. Human DUT Protein expressed in Escherichia coli (E. coli) - ABIN667220 : Persson, Cedergren-Zeppezauer, Wilson: Homotrimeric dUTPases; structural solutions for specific recognition and hydrolysis of dUTP. in Current protein & peptide science 2002 (PubMed)
    Show all 2 references for ABIN667220

More Proteins for Deoxyuridine Triphosphatase (DUT) Interaction Partners

Fruit Fly (Drosophila melanogaster) Deoxyuridine Triphosphatase (DUT) interaction partners

  1. revealed the importance of the PAA(10-12) tripeptide and the ID(17-18) dipeptide, as well as the role of the PAAK(10-13) segment in nuclear localization of dUTPase.

  2. there is a conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer

  3. kinetic characterization, folding, and crystallographic studies of dUTPase

  4. dUTPase is developmentally regulated in Drosophila melanogaster

  5. dUTPase, a recently described eukaryotic model, has a similar affinity of binding towards alpha,beta-imino-dUTP as compared to the prokaryotic E. coli enzyme

  6. dUTPase localization character showed strict timing to the nuclear cleavage phases and explained how its isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle.

Human Deoxyuridine Triphosphatase (DUT) interaction partners

  1. Comparison of the cellular distribution of wild-type dUTPase with those of hyperphosphorylation- and hypophosphorylation-mimicking mutants suggests that phosphorylation at Ser11 leads to the exclusion of dUTPase from the nucleus.

  2. EBV-encoded dUTPase may act as an intercellular signaling molecule capable of modulating the cellular microenvironment

  3. Data sugget that inhibition of dUTPase is a mechanism-based therapeutic approach to significantly enhance the efficacy of thymidylate synthase (show TYMS Proteins) (TS)-targeted chemotherapeutic agents.

  4. Repression of dUTPase induced specific expression level increments for thymidylate kinase (show DTYMK Proteins) and thymidine kinase (show TK1 Proteins), and also an increased sensitization to 5-fluoro-2'-deoxyuridine and 5-fluoro-uracil.

  5. High dUTP pyrophosphatase is associated with recurrence in colorectal cancer patients undergoing 5-fluorouracil adjuvant chemotherapy

  6. nuclear dUTPase may be a good biomarker for predicting prognosis in HCC (show FAM126A Proteins) patients after surgical resection

  7. Novel gain of function activity of p53 (show TP53 Proteins) mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

  8. Nuclear dUTPase may contain a complex nuclear localization signal that is located throughout the entire protein.

  9. dUTPase staining provides a useful measure of cell proliferation distinct from that offered by Ki-67 (show MKI67 Proteins) labeling. It proved particularly useful for the evaluation of diffuse astrocytomas.

  10. kinetic model of the human dUTPase catalytic cycle

Mouse (Murine) Deoxyuridine Triphosphatase (DUT) interaction partners

  1. Novel gain of function activity of p53 (show TP53 Proteins) mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

Deoxyuridine Triphosphatase (DUT) Protein Profile

Protein Summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Gene names and symbols associated with DUT

  • deoxyuridine triphosphatase (DUT)
  • Deoxyuridine triphosphatase (dUTPase)
  • deoxyuridine triphosphatase (P18)
  • deoxyuridine triphosphatase (AlHV1gp51)
  • deoxyuridine triphosphatase (UL50)
  • deoxyuridine triphosphatase (HVT058)
  • deoxyuridine triphosphatase (ORF9)
  • deoxyuridine triphosphatase (ORF8)
  • deoxyuridine triphosphatase (U45)
  • deoxyuridine triphosphatase (ORF54)
  • deoxyuridine triphosphatase (Tc00.1047053509151.130)
  • deoxyuridine triphosphatase (Tc00.1047053508175.160)
  • deoxyuridine triphosphatase (Tb927.7.5160)
  • deoxyuridine triphosphatase (dut)
  • deoxyuridine triphosphatase (Dut)
  • 5031412I06Rik protein
  • 5133400F09Rik protein
  • anon-SAGE:Wang-077 protein
  • BcDNA:LD08534 protein
  • CG4584 protein
  • D2Bwg0749e protein
  • Dmel\\CG4584 protein
  • Dutp protein
  • dutpase protein
  • LD08534 protein
  • PIP4 protein
  • Tb07.27E10.390 protein
  • UTPase protein

Protein level used designations for DUT

dUTP pyrophosphatase , CG4584-PA , CG4584-PB , CG4584-PC , CG4584-PD , anon-SAGE:Wang-077 , dUTPase-PA , dUTPase-PB , dUTPase-PC , dUTPase-PD , deoxyuridine triphosphatase , deoxyuridine 5'-triphosphate nucleotidohydrolase , deoxyuridine triphosphatase, dUTPase, P18 , dUTP nucleotidohydrolase , deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial , PPAR-interacting protein 4 , dUTPase

GENE ID SPECIES
714401 Macaca mulatta
34529 Drosophila melanogaster
544274 Solanum lycopersicum
911778 Alcelaphine herpesvirus 1
911900 Gallid herpesvirus 3
918521 Meleagrid herpesvirus 1
1487339 Human herpesvirus 2
1487399 Bovine herpesvirus 1
1487647 Equid herpesvirus 4
1487671 Human herpesvirus 3
1487924 Human herpesvirus 6A
1497169 Murid herpesvirus 4
2703421 Human herpesvirus 1
3545542 Trypanosoma cruzi strain CL Brener
3553795 Trypanosoma cruzi strain CL Brener
3658718 Trypanosoma brucei brucei strain 927/4 GUTat10.1
100037200 Xenopus laevis
1854 Homo sapiens
609526 Canis lupus familiaris
110074 Mus musculus
497778 Rattus norvegicus
507945 Bos taurus
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