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anti-Der1-Like Domain Family, Member 1 (DERL1) Antibodies

The protein encoded by DERL1 is a member of the derlin family. Additionally we are shipping Der1-Like Domain Family, Member 1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DERL1 67819 Q99J56
DERL1 79139 Q9BUN8
DERL1 362912  
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Top anti-Der1-Like Domain Family, Member 1 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometry analysis of Hela cells using DERL1 Antibody (C-term) Cat.-No AP17987PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with DERL1 Antibody (C-term) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chinese Hamster Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Detection of Derlin protein in canine KRM microsomes using ABIN151899. Staining of human liver using ABIN151899. 0.025 mL Log in to see 5 to 7 Days
$178.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of DERL1 Antibody (C-term) (ABIN652693) in NIH-3T3 cell line lysates (35 µg/lane). DERL1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with DERL1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$449.17
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC   0.1 mg Log in to see 5 to 7 Days
$330.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated ELISA, WB DERL1 monoclonal antibody (M01), clone 1B9. Western Blot analysis of DERL1 expression in HeLa. 100 μg Log in to see 9 Days
$430.00
Details

DERL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Der1-Like Domain Family, Member 1 Antibodies

  1. Human Polyclonal DERL1 Primary Antibody for IHC - ABIN965990 : Lilley, Ploegh: A membrane protein required for dislocation of misfolded proteins from the ER. in Nature 2004 (PubMed)
    Show all 3 references for ABIN965990

  2. Human Polyclonal DERL1 Primary Antibody for EIA, FACS - ABIN453618 : Oda, Okada, Yoshida, Kaufman, Nagata, Mori: Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. in The Journal of cell biology 2006 (PubMed)
    Show all 2 references for ABIN453618

More Antibodies against Der1-Like Domain Family, Member 1 Interaction Partners

Mouse (Murine) Der1-Like Domain Family, Member 1 (DERL1) interaction partners

  1. Cav-1 (show CAV1 Antibodies) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 (show COX2 Antibodies) and may facilitate Derlin-1- and p97 (show EIF4G2 Antibodies) complex-mediated COX-2 (show COX2 Antibodies) ubiquitination, retrotranslocation, and degradation.

  2. Derlin-1 deficiency is embryonic lethal, Derlin-3 (show DERL3 Antibodies) deficiency appears normal, and Herp (show HERPUD1 Antibodies) deficiency is intolerant to glucose load and ischemia in mice

  3. Derlin-1 regulates the turnover of superoxide dismutase 1 (show SOD1 Antibodies) by promoting the proteasomal and autophagosomal degradation of SOD1 (show SOD1 Antibodies) protein, but not by decreasing mutant SOD1 (show SOD1 Antibodies) mRNA levels.

  4. Perturbation of binding between SOD1 (show SOD1 Antibodies)(mut (show MUT Antibodies)) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1 (show SOD1 Antibodies)(mut (show MUT Antibodies))-induced ER stress, ASK1 (show MAP3K5 Antibodies) activation, and motor neuron death.

Human Der1-Like Domain Family, Member 1 (DERL1) interaction partners

  1. Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells.

  2. TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1.

  3. Cav-1 (show CAV1 Antibodies) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 (show COX2 Antibodies) and may facilitate Derlin-1- and p97 (show EIF4G2 Antibodies) complex-mediated COX-2 (show COX2 Antibodies) ubiquitination, retrotranslocation, and degradation.

  4. Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR (show EGFR Antibodies)-ERK (show EPHB2 Antibodies)-mediated up-regulation of MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies).

  5. Upregulation of derlin-1 may be associated with endoplasmic reticulum stress in neuronal cells in Alzheimer's disease.

  6. These results indicate that ApoB (show APOB Antibodies) after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 (show FAF2 Antibodies) are engaged in the predislocation and postdislocation steps, respectively.

  7. Derlin-1 expression levels may affect glucose-stimulated insulin (show INS Antibodies) secretion by altering surface expression of K(ATP) channels.

  8. Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP (show ABCG2 Antibodies) expression and provide a novel posttranslational regulatory mechanism of BCRP (show ABCG2 Antibodies) by Derlin-1.

  9. Derlin-1 is an important factor for the extraction of certain aberrantly folded proteins from the mammalian ER

  10. Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP (show SELS Antibodies), a novel membrane protein that recruits the p97 ATPase (show vcp Antibodies) and its cofactor

Cow (Bovine) Der1-Like Domain Family, Member 1 (DERL1) interaction partners

  1. A role for DERL1 in tissue remodeling events and maintenance of function in reproductive tissues.

Der1-Like Domain Family, Member 1 (DERL1) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene names and symbols associated with DERL1

  • Derlin-1 (Der-1) antibody
  • derlin-1 (EDI_023440) antibody
  • derlin-1.1 (PTRG_01331) antibody
  • hypothetical protein (derl1) antibody
  • Der1-like domain family, member 1 (DERL1) antibody
  • Der1-like domain family, member 1 (derl1) antibody
  • derlin 1 (DERL1) antibody
  • derlin 1 (derl1) antibody
  • Der1-like domain family, member 1 (LOC100355027) antibody
  • Der1-like domain family, member 1 (Derl1) antibody
  • derlin 1 (Derl1) antibody
  • derlin-1 (DER1) antibody
  • 1110021N07Rik antibody
  • AI195141 antibody
  • AW551338 antibody
  • CG10908 antibody
  • DDBDRAFT_0188135 antibody
  • DDBDRAFT_0266772 antibody
  • DDB_0188135 antibody
  • DDB_0266772 antibody
  • DER-1 antibody
  • DER1 antibody
  • DERLIN-1 antibody
  • Dmel\\CG10908 antibody
  • F17A13.150 antibody
  • F17A13_150 antibody
  • MGC84200 antibody
  • RGD1311835 antibody
  • wu:fb09d07 antibody
  • wu:fb94d05 antibody
  • wu:fj92g12 antibody
  • zgc:55637 antibody

Protein level used designations for DERL1

CG10908-PA , CG10908-PB , Der-1-PA , Der-1-PB , Dm Derlin-1 , derlin-1 , derlin-1.1 , Der1-like domain family, member 1 , Der1-like protein 1 , degradation in endoplasmic reticulum protein 1 , der1-like protein 1 , DERtrin-1

GENE ID SPECIES
33369 Drosophila melanogaster
5882626 Entamoeba dispar SAW760
6338400 Pyrenophora tritici-repentis Pt-1C-BFP
8626833 Dictyostelium discoideum AX4
100158198 Sus scrofa
100528714 Ictalurus punctatus
444811 Xenopus laevis
464364 Pan troglodytes
549477 Xenopus (Silurana) tropicalis
703803 Macaca mulatta
100355027 Oryctolagus cuniculus
406753 Danio rerio
67819 Mus musculus
420350 Gallus gallus
79139 Homo sapiens
475086 Canis lupus familiaris
404121 Bos taurus
362912 Rattus norvegicus
100172781 Pongo abelii
829054 Arabidopsis thaliana
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