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Der1-Like Domain Family, Member 1 Proteins (DERL1)

The protein encoded by DERL1 is a member of the derlin family. Additionally we are shipping Der1-Like Domain Family, Member 1 Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DERL1 67819 Q99J56
DERL1 79139 Q9BUN8
Rat DERL1 DERL1 362912  
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Top Der1-Like Domain Family, Member 1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

DERL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Der1-Like Domain Family, Member 1 (DERL1) Interaction Partners

Mouse (Murine) Der1-Like Domain Family, Member 1 (DERL1) interaction partners

  1. Cav-1 (show CAV1 Proteins) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 (show EIF4G2 Proteins) complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.

  2. Derlin-1 deficiency is embryonic lethal, Derlin-3 (show DERL3 Proteins) deficiency appears normal, and Herp (show HERPUD1 Proteins) deficiency is intolerant to glucose load and ischemia in mice

  3. Derlin-1 regulates the turnover of superoxide dismutase 1 (show SOD1 Proteins) by promoting the proteasomal and autophagosomal degradation of SOD1 (show SOD1 Proteins) protein, but not by decreasing mutant SOD1 (show SOD1 Proteins) mRNA levels.

  4. Perturbation of binding between SOD1 (show SOD1 Proteins)(mut (show MUT Proteins)) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1 (show SOD1 Proteins)(mut (show MUT Proteins))-induced ER stress, ASK1 (show MAP3K5 Proteins) activation, and motor neuron death.

Human Der1-Like Domain Family, Member 1 (DERL1) interaction partners

  1. Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells.

  2. TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1.

  3. Cav-1 (show CAV1 Proteins) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 (show EIF4G2 Proteins) complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.

  4. Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR (show EGFR Proteins)-ERK (show EPHB2 Proteins)-mediated up-regulation of MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins).

  5. Upregulation of derlin-1 may be associated with endoplasmic reticulum stress in neuronal cells in Alzheimer's disease.

  6. These results indicate that ApoB (show APOB Proteins) after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 (show FAF2 Proteins) are engaged in the predislocation and postdislocation steps, respectively.

  7. Derlin-1 expression levels may affect glucose-stimulated insulin (show INS Proteins) secretion by altering surface expression of K(ATP) channels.

  8. Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression and provide a novel posttranslational regulatory mechanism of BCRP by Derlin-1.

  9. Derlin-1 is an important factor for the extraction of certain aberrantly folded proteins from the mammalian ER

  10. Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP (show SELS Proteins), a novel membrane protein that recruits the p97 ATPase (show vcp Proteins) and its cofactor

Cow (Bovine) Der1-Like Domain Family, Member 1 (DERL1) interaction partners

  1. A role for DERL1 in tissue remodeling events and maintenance of function in reproductive tissues.

Der1-Like Domain Family, Member 1 (DERL1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene names and symbols associated with DERL1

  • Derlin-1 (Der-1)
  • derlin-1 (EDI_023440)
  • derlin-1.1 (PTRG_01331)
  • hypothetical protein (derl1)
  • Der1-like domain family, member 1 (DERL1)
  • Der1-like domain family, member 1 (derl1)
  • derlin 1 (DERL1)
  • derlin 1 (derl1)
  • Der1-like domain family, member 1 (LOC100355027)
  • Der1-like domain family, member 1 (Derl1)
  • derlin 1 (Derl1)
  • derlin-1 (DER1)
  • 1110021N07Rik protein
  • AI195141 protein
  • AW551338 protein
  • CG10908 protein
  • DDBDRAFT_0188135 protein
  • DDBDRAFT_0266772 protein
  • DDB_0188135 protein
  • DDB_0266772 protein
  • DER-1 protein
  • DER1 protein
  • DERLIN-1 protein
  • Dmel\\CG10908 protein
  • F17A13.150 protein
  • F17A13_150 protein
  • MGC84200 protein
  • RGD1311835 protein
  • wu:fb09d07 protein
  • wu:fb94d05 protein
  • wu:fj92g12 protein
  • zgc:55637 protein

Protein level used designations for DERL1

CG10908-PA , CG10908-PB , Der-1-PA , Der-1-PB , Dm Derlin-1 , derlin-1 , derlin-1.1 , Der1-like domain family, member 1 , Der1-like protein 1 , degradation in endoplasmic reticulum protein 1 , der1-like protein 1 , DERtrin-1

GENE ID SPECIES
33369 Drosophila melanogaster
5882626 Entamoeba dispar SAW760
6338400 Pyrenophora tritici-repentis Pt-1C-BFP
8626833 Dictyostelium discoideum AX4
100158198 Sus scrofa
100528714 Ictalurus punctatus
444811 Xenopus laevis
464364 Pan troglodytes
549477 Xenopus (Silurana) tropicalis
703803 Macaca mulatta
100355027 Oryctolagus cuniculus
406753 Danio rerio
67819 Mus musculus
420350 Gallus gallus
79139 Homo sapiens
475086 Canis lupus familiaris
404121 Bos taurus
362912 Rattus norvegicus
100172781 Pongo abelii
829054 Arabidopsis thaliana
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