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Der1-Like Domain Family, Member 2 Proteins (DERL2)

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. Additionally we are shipping Der1-Like Domain Family, Member 2 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DERL2 DERL2 691956  
DERL2 116891 Q8BNI4
DERL2 51009 Q9GZP9
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Top Der1-Like Domain Family, Member 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DERL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Der1-Like Domain Family, Member 2 (DERL2) Interaction Partners

Mouse (Murine) Der1-Like Domain Family, Member 2 (DERL2) interaction partners

  1. Whole-body deletion of derlin-2 leads to perinatal lethality and skeletal abnormalities.

Human Der1-Like Domain Family, Member 2 (DERL2) interaction partners

  1. specific silencing of Derlin-2, p97 (show EIF4G2 Proteins) and HRD1 (show SYVN1 Proteins) by shRNAs increases steady state levels of proinsulin (show INS Proteins). these ERAD constituents are critically involved in proinsulin (show INS Proteins) degradation and may therefore also play a role in subsequent antigen generation.

  2. derlin2 functions with HRD1 (show SYVN1 Proteins) in ERAD of certain substrates independent of their glycosylation status.

  3. Derlin-2 forms a robust multiprotein complex with the p97 AAA ATPase as well as the mammalian orthologs of the yeast Hrd1p/Hrd3p ubiquitin-ligase complex, and participates in the degradation of proteins from the ER.

  4. Findings indicate that Derlin-2 provides the missing link between EDEM (show EDEM1 Proteins) and p97 (show EIF4G2 Proteins) in the process of degrading misfolded glycoproteins.

Der1-Like Domain Family, Member 2 (DERL2) Protein Profile

Protein Summary

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006

Gene names and symbols associated with DERL2

  • Der1-like domain family, member 2 (DERL2)
  • derlin 2 (DERL2)
  • derlin 2 (derl2)
  • Der1-like domain family, member 2 (derl2)
  • Der1-like domain family, member 2 (Derl2)
  • derlin-2.2 (DER2.2)
  • derlin-2.1 (DER2.1)
  • derlin-2 (PVX_117040)
  • derlin-2.1 (CpipJ_CPIJ012528)
  • derlin-2 (SJAG_00681)
  • hypothetical protein (derl2)
  • derlin-2 (MCYG_03163)
  • derlin-2 (VDBG_06959)
  • derlin-2 (LOAG_05811)
  • derlin-2 (MGYG_00329)
  • Derlin-2 (derl2)
  • Der1-like domain family, member 2 (LOC100345788)
  • Derlin-2 (Der-2)
  • BC005682 protein
  • Cg14899 protein
  • CGI-101 protein
  • DDBDRAFT_0186360 protein
  • DDBDRAFT_0266773 protein
  • DDB_0186360 protein
  • DDB_0266773 protein
  • DER1 protein
  • derl2 protein
  • Derlin-2 protein
  • DERLIN-2.1 protein
  • DERLIN-2.2 protein
  • Dmel\\CG14899 protein
  • F-LAN-1 protein
  • F-LANa protein
  • FLANa protein
  • RP23-83I13.8 protein
  • T4B21.2 protein
  • T4B21_2 protein
  • T8O5.20 protein
  • T8O5_20 protein
  • zgc:110436 protein

Protein level used designations for DERL2

Der1-like domain family, member 2 , derlin 2 , derlin-2 , derlin-2.1 , Derlin-2 , CG14899-PA , Der-2-PA , carcinoma related , degradation in endoplasmic reticulum protein 2 , der1-like protein 2 , DERtrin-2

GENE ID SPECIES
417498 Gallus gallus
455251 Pan troglodytes
508465 Bos taurus
548851 Xenopus (Silurana) tropicalis
554093 Danio rerio
606991 Canis lupus familiaris
691956 Rattus norvegicus
825823 Arabidopsis thaliana
828269 Arabidopsis thaliana
5475001 Plasmodium vivax Sal-1
6045779 Culex quinquefasciatus
7050717 Schizosaccharomyces japonicus yFS275
8624956 Dictyostelium discoideum AX4
9230339 Arthroderma otae CBS 113480
9527382 Verticillium alfalfae VaMs.102
9943219 Loa loa
10031556 Arthroderma gypseum CBS 118893
100195686 Salmo salar
100345788 Oryctolagus cuniculus
100381029 Xenopus laevis
42005 Drosophila melanogaster
116891 Mus musculus
51009 Homo sapiens
100174373 Pongo abelii
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