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The protein encoded by DSC1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Additionally we are shipping Desmocollin 1 Antibodies (57) and Desmocollin 1 Kits (10) and many more products for this protein.
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Increased expression of DSC1 (show RCAN1 Proteins) can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 (show RCAN1 Proteins) also indicates a poor prognosis of the patients with HNSCC.
Low expression of DSC 1 (show RCAN1 Proteins), 2, and 3 was observed in 55, 54, and 79 % of liver metastases.
High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 (show DSC2 Proteins) in 58.0%, DSC3 (show DSC2 Proteins) in 61.4%, E-cadherin (show CDH1 Proteins) in 71.4%, CDX2 (show CDX2 Proteins) in 58.0%, PITX1 (show PITX1 Proteins) in 55.0%, CDK4 (show CDK4 Proteins) in 0.2%, TLE1 (show TLE1 Proteins) in 1.3%, Factor H (show CFH Proteins) in 42.5%, and MDM2 (show MDM2 Proteins) in 0.2% of colorectal carcinomas.
The ultrastructural modifications of desmosomes during terminal differentiation of hair follicles are paralleled by the modulation of the synthesis of desmocollin 1.
in majority of patients with Netherton syndrome, Dsg1 (show DSG1 Proteins) & Dsc1 (show RCAN1 Proteins) were reduced in living layers of epidermis; SCTE (show KLK5 Proteins)-like & SCCE (show KLK7 Proteins)-like activities were increased, suggesting these proteases participate in premature degradation of corneodesmosomal cadherins
Increased Dsc1 (show RCAN1 Proteins) protein is associated with colorectal cancer
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
, cadherin family member 1
, desmosomal glycoprotein 2/3