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The protein encoded by DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Additionally we are shipping Desmocollin 2 Antibodies (44) and Desmocollin 2 Kits (5) and many more products for this protein.
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Human Desmocollin 2 Protein expressed in Human Cells - ABIN2003427
Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. in Journal of proteome research 2005
Show all 3 references for ABIN2003427
Rat (Rattus) Desmocollin 2 Protein expressed in Human Cells - ABIN2009399
Ramachandran, Boontheung, Xie, Sondej, Wong, Loo: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. in Journal of proteome research 2006
Show all 3 references for ABIN2009399
Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3 (show PKP3 Proteins)) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2 (show DSG2 Proteins)).
Oxidized low-density lipoprotein attenuated desmoglein 1 (show DSG1 Proteins) and desmocollin 2 expression in human umbilical vein endothelial cells.
DSC2 promoter methylation is associated with Breast Cancer.
Homozygous founder mutation in DSC2 gene identified among Italian arrhythmogenic cardiomyopathy probands, providing evidence of the occurrence of recessive DSC2 mutations presenting with biventricular forms of the disease.
Desmocollin-2 mutations are described for dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, as well. Desmocollin-2 mutation was described in a case of arrhythmogenic biventricular cardiomyopathy
a novel Nrf2 (show GABPA Proteins)-miR (show MLXIP Proteins)-29-Dsc2 axis controls desmosome function and cutaneous homeostasis
ECG reliably identifies homozygous p.Gln554X desmocollin-2 carriers and may be useful as an initial step in the screening of high-risk Hutterites.
DSC2 may be involved in the regulation of the invasive behavior of cells by a mechanism that controls cellcell attachment and cytoskeleton rearrangement
Data demonstrate that partner desmosomal cadherins Dsg2 (show DSG2 Proteins) and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (show EGFR Proteins) signaling.
Low expression of DSC 1 (show RCAN1 Proteins), 2, and 3 was observed in 55, 54, and 79 % of liver metastases.
plakoglobin (show JUP Proteins) (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1 (show LEF1 Proteins)) differentially regulates the proximal promoters of Dsc2 and Dsc3 (show DSC3 Proteins)
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.
desmocollin type 2
, desmocollin 2
, desmocollin 3
, cadherin family member 2
, desmosomal glycoprotein II/III
, epithelial type 2 desmocollin