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Component of intercellular desmosome junctions.
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Sgk1 (show SGK1 Proteins) regulates Dsg1c expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.
Expressed in brain, skeletal muscle, and liver, among other tissues. Similar to Dsg2 in its tissue distribution. Orthologous Dsg1 gamma was not found in human genome, suggesting desmosomal cadherin gene cluster contracted during mammalian evolution.
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.