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Desmoglein 2 Proteins (DSG2)

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Additionally we are shipping Desmoglein 2 Antibodies (111) and Desmoglein 2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DSG2 1829 Q14126
DSG2 13511 O55111
Rat DSG2 DSG2 307562  
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Top Desmoglein 2 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details

DSG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Desmoglein 2 (DSG2) Interaction Partners

Zebrafish Desmoglein 2 (DSG2) interaction partners

Human Desmoglein 2 (DSG2) interaction partners

  1. a novel pathway of CSTA (show CSTA Proteins) regulation involving Dsg2

  2. DSG2 and DSG3 (show DSG3 Proteins) might be potential diagnostic markers for squamous cell carcinoma of the lung.

  3. In endometrial luminal epithelium, cadherin 6 (show CDH6 Proteins), desmoglein 2 and plexin b2 (show PLXNB2 Proteins) were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.

  4. a low DSG2 expression phenotype is a useful prognostic biomarker of tumor aggressiveness and may serve as an aid in identifying patients with clinically significant prostate cancer.

  5. Six variants of uncertain clinical significance in the PKP2, JUP (show JUP Proteins), and DSG2 genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Proteins)/C-related pathogenic splice site mutations.

  6. This structure reveals that the ectodomain of Dsg2 is flexible even in the calcium-bound state and, on average, is shorter than the type 1 cadherin crystal structures.

  7. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 (show DSC2 Proteins) play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (show EGFR Proteins) signaling.

  8. Desmoglein 2 expression attenuates migration of melanoma cells, mediated by downregulation of secretogranin II (show SCG2 Proteins).

  9. Reduced cardiac desmoglein-2 and desmocollin-2 (show DSC2 Proteins) levels appear to be specifically associated with Arrhythmogenic right ventricular Dysplasia/cardiomyopathy, independent of underlying mutations.

  10. Gal3 has a role in stabilizing desmoglein-2, a desmosomal cadherin, and intercellular adhesion in intestinal epithelial cells

Mouse (Murine) Desmoglein 2 (DSG2) interaction partners

  1. Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC).

  2. Dsg2 modulates Gli1 (show GLI1 Proteins) expression. Dsg2-mediated hyperproliferation, MEK (show MDK Proteins)/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1 (show PTCH1 Proteins)+/lacZ (show GLB1 Proteins) background.

  3. a novel pathway of CSTA (show CSTA Proteins) regulation involving Dsg2

  4. Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function.

  5. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 (show DSC2 Proteins) play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (show EGFR Proteins) signaling.

  6. Dsg2 compensates for Dsg3 (show DSG3 Proteins) depletion with regard to cell cohesion, but does not regulate p38 MAPK (show MAPK14 Proteins) signaling.

  7. In vivo interaction between Dsg2 and Na(V)1.5 provides a molecular pathway for the observed electrical disturbances during the early arrhythmogenic right ventricular cardiomyopathy.

  8. Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement.

  9. ventricular arrhythmias that has been linked to mutations in desmosomal proteins including desmoglein 2

  10. Myocyte necrosis underlies progressive myocardial dystrophy in N271S-dsg2-related arrhythmogenic right ventricular cardiomyopathy.

Desmoglein 2 (DSG2) Protein Profile

Protein Summary

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

Gene names and symbols associated with Desmoglein 2 Proteins (DSG2)

  • desmoglein 2 (DSG2)
  • desmoglein 2 (dsg2)
  • desmoglein 2 (LOC100348149)
  • desmoglein 2 (Dsg2)
  • AA408168 protein
  • ARVC10 protein
  • ARVD10 protein
  • CDHF5 protein
  • CMD1BB protein
  • D18Ertd293e protein
  • dsc protein
  • DSG2 protein
  • dsga protein
  • HDGC protein
  • si:dkeyp-51f12.6 protein
  • wu:fj23f02 protein

Protein level used designations for Desmoglein 2 Proteins (DSG2)

desmoglein 2 , Dsg alpha , desmocollin a , desmoglein-2-like , HDGC , cadherin family member 5 , desmoglein-2

GENE ID SPECIES
100066038 Equus caballus
428529 Gallus gallus
455356 Pan troglodytes
560026 Danio rerio
705805 Macaca mulatta
100348149 Oryctolagus cuniculus
100456327 Pongo abelii
100565052 Anolis carolinensis
1829 Homo sapiens
13511 Mus musculus
307562 Rattus norvegicus
490500 Canis lupus familiaris
100625833 Sus scrofa
508151 Bos taurus
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