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May be involved in the maintenance of active epigenetic status of target genes (By similarity). Additionally we are shipping Developmental Pluripotency Associated 4 Proteins (6) and Developmental Pluripotency Associated 4 Kits (1) and many more products for this protein.
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Human Polyclonal DPPA4 Primary Antibody for EIA, IHC (p) - ABIN356927
Bortvin, Eggan, Skaletsky, Akutsu, Berry, Yanagimachi, Page, Jaenisch: Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. in Development (Cambridge, England) 2003
knockdown of PCGF1 (show PCGF1 Antibodies) results in reduced expression of DPPA4 and other subunits of the variant PRC1 (show PRC1 Antibodies) complex at both mRNA and protein levels
Results identified a new family of pluripotency-related oncogenes consisting of DPPA2 and (show DPPA2 Antibodies)DPPA4.
Thsi study identifies DPPA4 and other genes as putative Sox2 (show SOX2 Antibodies):Oct-3/4 (show POU5F1 Antibodies) target genes using a combination of in silico analysis and transcription-based assays.
Results have identified a new family of pluripotency-related oncogenes consisting of DPPA2 (show DPPA2 Antibodies) and DPPA4.
Study of expression and function of pluripotent markers such as Dppa2 (show DPPA2 Antibodies) and Dppa4 is likely to unveil new aspects of the regulation of pluripotency and germ line development in mammals.
DPPA4 is a nuclear factor associated with active chromatin
Dppa4 is completely dispensable for ES cell identity and germ cell development. Instead, loss of Dppa4 in mice results in late embryonic/perinatal death and striking skeletal defects with partial penetrance.
May be involved in the maintenance of active epigenetic status of target genes (By similarity). May inhibit differentiation of embryonic cells into a primitive ectoderm lineage (By similarity).
developmental pluripotency associated 4
, putative dipeptides/oligopeptides ABC transporter periplasmic substrate-binding protein
, dipeptide ABC transport system, substrate-binding protein
, developmental pluripotency-associated protein 4
, embryonic stem cell-associated transcript 15-1 protein
, Developmental pluripotency-associated protein 4