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Diacylglycerol Kinase, alpha 80kDa Proteins (DGKA)

The protein encoded by DGKA belongs to the eukaryotic diacylglycerol kinase family. Additionally we are shipping DGKA Antibodies (105) and DGKA Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DGKA 13139 O88673
DGKA 140866 P51556
DGKA 1606 P23743
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Top DGKA Proteins at antibodies-online.com

Showing 8 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,123.17
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$803.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DGKA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Rat (Rattus) ,
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Human , ,
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More Proteins for Diacylglycerol Kinase, alpha 80kDa (DGKA) Interaction Partners

Mouse (Murine) Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

  1. Our studies demonstrate that PKD1 (show PKD1 Proteins)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.

  2. Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

  3. Ovalbumin (show OVA Proteins)-induced airway inflammation was inhibited after DGKalpha DNA vaccine administation.

  4. Data indicate that combined deletion of dgkzeta (show DGKZ Proteins) and dgkalpha markedly enhances T-cell responses.

  5. The data strongly supported a role for FoxO (show FOXO3 Proteins) proteins in promoting high diacylglycerol kinase alpha levels and indicate a mechanism by which diacylglycerol kinase alpha function is downregulated during productive T cell responses.

  6. results suggest that the globular form of adiponectin (show ADIPOQ Proteins)-induced generation of reactive oxygen species and nitric oxide involves diacylglycerol kinase alpha

  7. DAG kinases (DGKs) alpha and zeta, which terminate DAG-mediated signaling, synergistically inhibit TCR-induced mTOR (show FRAP1 Proteins) activation by inhibiting the Ras-Mek1 (show MAP2K1 Proteins)/2-Erk (show EPHB2 Proteins)/12 pathway

  8. A role for DGK alpha in T cell activation is confirmed by the rapid DGK alpha translocation to the membrane fraction, together with the increase in enzyme activity that follows T cell activation in vivo.

  9. regulated by pi 3 (show PI3 Proteins)-kinase activation products

  10. Diacylglycerol kinase alpha is an anergy-associated molecule that negatively regulates Ras in anergic T cells.

Human Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

  1. An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed

  2. Decreased DNA methylation (show HELLS Proteins) at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1 (show EGR1 Proteins)) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis.

  3. These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells.

  4. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1 (show MICALL1 Proteins)

  5. High diacylglycerol kinase alpha expression is associated with glioblastoma.

  6. DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK (show MAPK1 Proteins) pathway.

  7. DGK-alpha was more highly expressed in CD8 (show CD8A Proteins)-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes.

  8. Antigen-specific CD8 (show CD8A Proteins)-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK (show DGKB Proteins)-deficient memory CD8 (show CD8A Proteins)+ T cells exhibit impaired expansion.

  9. SAP (show APCS Proteins)-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation

  10. Diacylglycerol kinase alpha is a key regulator of the polarised secretion of exosomes.

Pig (Porcine) Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

  1. the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl

DGKA Protein Profile

Protein Summary

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Gene names and symbols associated with DGKA

  • diacylglycerol kinase, alpha 80kDa (DGKA)
  • diacylglycerol kinase, alpha 80kDa (dgka)
  • diacylglycerol kinase, alpha a (dgkaa)
  • diacylglycerol kinase alpha (Tsp_02164)
  • diacylglycerol kinase, alpha (Dgka)
  • 80kDa protein
  • AW146112 protein
  • DAGK protein
  • DAGK1 protein
  • DGK-alpha protein
  • dgka protein
  • zgc:136759 protein

Protein level used designations for DGKA

diacylglycerol kinase, alpha 80kDa , diacylglycerol kinase alpha , diacylglycerol kinase alpha-like , 80 kDa diacylglycerol kinase , DAG kinase alpha , DGK-alpha , diacylglycerol kinase alpha Flt2-Pr2 , diglyceride kinase alpha , truncated diacylglycerol kinase alpha Flt1-Pr1

GENE ID SPECIES
451976 Pan troglodytes
564739 Danio rerio
710559 Macaca mulatta
724010 Danio rerio
10907457 Trichinella spiralis
100124931 Xenopus (Silurana) tropicalis
100172456 Pongo abelii
100347223 Oryctolagus cuniculus
100380983 Xenopus laevis
100405635 Callithrix jacchus
100593934 Nomascus leucogenys
13139 Mus musculus
140866 Rattus norvegicus
1606 Homo sapiens
506348 Bos taurus
397097 Sus scrofa
474393 Canis lupus familiaris
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